文献类型：期刊文献

英文题名：A mussel-inspired carboxymethyl cellulose hydrogel with enhanced adhesiveness through enzymatic crosslinking

作者：Zhong, Yujie[1];Wang, Jie[1];Yuan, Zhenyu[1];Wang, Yu[1];Xi, Zhenhao[2];Li, Li[1];Liu, Zhiyong[3];Guo, Xuhong[1,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[3]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Key Lab Mat Chem Engn Xinjiang Uygur Autonomous R, Shihezi 832000, Peoples R China

年份：2019

卷号：179

起止页码：462

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20191606802551);WOS:【SCI-EXPANDED(收录号:WOS:000471736600052)】；

基金：We gratefully thank NSFC Grants (51403062, 51273063 and 21476143), the Fundamental Research Funds for the Central Universities and 111 Project Grant (B08021) for financial support of this work.

语种：英文

外文关键词：Carboxymethyl cellulose; Mussel-inspired; Enzymatic crosslinking; Tissue adhesive

摘要：In order to replace conventional sutures in wound closing applications, favorable hydrogels with strong wet tissue adhesion and biocompatibility have attracted considerable attention. Herein, inspired by mussel adhesive protein, a series of dopamine modified carboxymethyl cellulose (CMC-DA) hydrogels were prepared in situ using enzymatic crosslinking in the presence of horseradish peroxidase (HRP) and H2O2. The biomimetic CMC-DA hydrogel exhibited about 6-fold enhanced wet tissue adhesion strength (28.5 kPa) over the commercial fibrin glue. In addition, the gelation time, swelling ratio and rheological property of the hydrogel can be simply controlled by changing the concentrations of HRP, H2O2, and CMC-DA polymer. The gels also exhibited good biodegradation and biocompatibility in vitro. The overall results show that the CMC-DA hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.