文献类型：期刊文献

中文题名：壳聚糖衍生物在抗肿瘤方面的研究进展

英文题名：Research progress of chitosan derivatives in antitumor studies

作者：王晓霁[1];杨靖亚[1];刘建文[2]

机构：[1]上海海洋大学食品学院,上海200090;[2]华东理工大学药学院,上海200237

年份：2008

卷号：13

期号：8

起止页码：952

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

基金：上海市重点学科建设项目(T1102)

语种：中文

中文关键词：壳聚糖衍生物;抗肿瘤;载体

外文关键词：chitosan derivatives; antitumor; carrier

摘要：随着科学理论和实践研究的进展,壳聚糖衍生物在抗肿瘤方面应用有所突破。壳聚糖衍生物因其稳定性、生物相容性、生物可降解性、低毒性、体内长期保留性等优点,显示出了良好的研究前景。本文综述了壳聚糖衍生物抗肿瘤性质、作为药物载体应用以及对物理治疗辅助作用。这些资料都说明了壳聚糖衍生物在抑制肿瘤生长和延长存活期方面起到了积极作用。
Application of chitosan derivatives in antitumor studies had gained great progress with the development of theory and practiee, whieh exhibited good prospect for its favourable properties, such as stability, biocompatibility, biodegradability, low toxieity and long-term retention in the body. Antitumor properties of chitosan derivatives, application of chitosan derivatives as drug earrier and auxiliary function of physieal thempy were concluded in this review. The data showed that chitosan derivatives played an active role in suppression of tumour growth and prolongation of survival period.