文献类型：期刊文献

英文题名：A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds

作者：Hong, Yi[1,2,3,4];Zhou, Feifei[1,2,3,4];Hua, Yujie[5];Zhang, Xianzhu[1,2,3,4];Ni, Chengyao[6];Pan, Dihao[6];Zhang, Yiqing[5];Jiang, Deming[1,2,3,4];Yang, Long[1,2,3,4];Lin, Qiuning[5];Zou, Yiwei[1,2,3,4];Yu, Dongsheng[1,2,3,4];Arnot, David E.[1,2,3];Zou, Xiaohui[7];Zhu, Linyong[5];Zhang, Shufang[1,2,3,4,8];Ouyang, Hongwei[1,2,3,4,8,9,10]

机构：[1]Zhejiang Univ, Affiliated Hosp 2, Dept Orthopaed Surg, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China;[2]Zhejiang Univ, Zhejiang Univ Univ Edinburgh Inst, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China;[3]Zhejiang Univ, Sch Basic Med, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China;[4]Zhejiang Univ, Sch Med, Dr Li Dak Sum & Yip Yio Chin Ctr Stem Cells & Reg, Hangzhou 310003, Zhejiang, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem & Mol Engn, State Key Lab Bioreactor Engn, Optogenet & Synthet Biol Interdisciplinary Res Ct, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[6]Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Cardiothorac Surg, Hangzhou 310003, Zhejiang, Peoples R China;[7]Zhejiang Univ, Affiliated Hosp 1, Sch Med, Clin Res Ctr, Hangzhou 310003, Zhejiang, Peoples R China;[8]China Orthoped Regenerat Med Grp CORMed, Hangzhou 310003, Zhejiang, Peoples R China;[9]Zhejiang Univ, Sch Med, Key Lab Tissue Engn & Regenerat Med Zhejiang Prov, Hangzhou 310003, Zhejiang, Peoples R China;[10]Zhejiang Univ, Sch Med, Dept Sports Med, Hangzhou 310003, Zhejiang, Peoples R China

年份：2019

卷号：10

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000467833000001)】；

基金：This work is supported by the National Key R&D Program of China (2017YFA0104900) and the NSFC grants (31830029, 81630065, 21425311, and 81672162). We thank Mr Nianhang Rong for the SEM imaging and thank the excellent technical assistance of Imaging Facility, Core Facilities, Zhejiang University School of Medicine, with the confocal laser microscopy; we thank Miss Qiulin He for her help with histological staining, and Mr Jun Li and Mr Youguo Liao for their help with the animal experiments. We thank the Institute of Biophysics, Chinese Academy of Sciences, and Jianguo Zhang and Wei Ji for cryo-SEM work.

语种：英文

摘要：Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60-160 mm Hg). Most importantly, the hydrogel can stop high pressure bleeding from pig carotid arteries with 4-5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.