文献类型：期刊文献

英文题名：Palladium-Catalyzed Site-Selective Benzocylization of Aromatic Acids with o-Fluoro-Substituted Diaryliodonium Salts toward 3,4-Benzocoumarins

作者：Pan, Cheng[1,2];Wang, Limin[1,2];Han, Jianwei[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Hong Kong Joint Lab Chem Synth, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2020

卷号：22

期号：12

起止页码：4776

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000543669800036)，CCR-EXPANDED(收录号:WOS:000543669800036)】；

基金：The work was supported by NSFC/China (21772039, 21421004), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the Programme of Introducing Talents of Discipline to Universities (B16017), National Key Research and Development Program (2016YFA0200302), as well as by the Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant.

语种：英文

摘要：By using 2-fluoro-substituted diaryliodonium salts, a novel benzocylization has been accomplished for the synthesis of 3,4-benzocoumarin derivatives via a cascade of ortho-arylation and defluorination in the presence of palladium catalysts. The reaction exhibits a broad compatibility of readily available aromatic acids with an excellent level of site-selectivity. Mechanistic investigations revealed a unique reactivity of carboxylic acid directed arylation by followed nucleophilic substitution of aromatic fluoride in the present system.