文献类型：期刊文献

英文题名：Axially Chiral Copper Catalyst for Asymmetric Synthesis of Valuable Diversely Substituted BINOLs

作者：Gao, Jun[1,2];Wang, Pengyang[1,2];Shen, Ahui[1,2];Yang, Xueyan[1,2];Cen, Shouyi[1,2];Zhang, Zhipeng[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Sci Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2024

卷号：14

期号：8

起止页码：5621

外文期刊名：ACS CATALYSIS

收录：;EI(收录号：20241515854580);WOS:【SCI-EXPANDED(收录号:WOS:001194392400001)】；

基金：We thank the Research Center of Analysis and Test, East China University of Science and Technology, for the help on the characterization. We acknowledge the National Natural Science Foundation of China (22371072 and 21702059), Fundamental Research Funds for the Central Universities (222201717003, JKJ01231652, JKVJ1231010, and SLJ13233303), Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), Program of Introducing Talents of Discipline to Universities (B16017), and the "Thousand Plan" Youth program for financial support.

语种：英文

外文关键词：enantioselective; copper; BINOL; oxidativecoupling; axial chirality; 2-naphthols

摘要：Optically pure BINOL (1,1 '-bi-2-naphthol) and diversely substituted BINOLs are highly valuable chiral motifs featuring axial chirality widely applied in various fields. Although unsubstituted BINOL is commercially available, the catalytic asymmetric synthesis of optically pure diversely substituted BINOLs is still very challenging. Herein, we report the development of a highly enantioselective dinuclear copper catalyst for oxidative homo- and cross-coupling of a variety of 2-naphthols to provide access to a broad range of highly valuable diversely substituted C-2- and C-1-symmetric BINOLs in up to 92% yield with high enantioselectivities (up to 99.5:0.5 er).