文献类型：期刊文献

英文题名：Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier

作者：Chen, Yan-Zuo[1,2,3];Huang, Yu-Kun[1,2];Chen, Yuan[2,4];Ye, Ya-Jing[1,2];Lou, Kai-Yan[2];Gao, Feng[1,2,3]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[4]Shanghai Inst Hlth Sci, Shanghai 201318, Peoples R China

年份：2015

卷号：26

期号：7

起止页码：909

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000359027500021)】；

基金：This work was financially supported by Postdoctoral Science Foundation of China (No. 2014M550222), Shanghai Postdoctoral Sustentation Fund (No. 14R21410500). The authors also acknowledge the support from School of Pharmacy, Fudan University & the Open Project Program of Key Lab of Smart Drug Delivery (Fudan University), Ministry of Education (No. SDD2014-2), State Key Laboratory of Molecular Engineering of Polymers (Fudan University, No. K2015-15), and the Fundamental Research Funds for the Central Universities (Nos. 22A201514055 and WY1213013 ECUST).

语种：英文

外文关键词：Chitosan; Cyclodextrin derivatives; Ionic gelation method; Drug delivery system

摘要：This research was aim to develop novel cyclodextrin/chitosan (CD/CS) nanocarriers for insoluble drug delivery through the mild ionic gelation method previously developed by our lab. A series of different beta-cyclodextrin (beta-CD) derivatives were incorporated into CS nanoparticles including hydroxypropyl-beta-cyclodextrin (HP-beta-CD), sulphobutylether-beta-cyclodextrin (SB-beta-CD), and 2,6-di-O-methy-beta-cyclodextrin (DM-beta-CD). Various process parameters for nanoparticle preparation and their effects on physicochemical properties of CD/CS nanoparticles were investigated, such as the type of CD derivatives, CD and CS concentrations, the mass ratio of CS to TPP (CS/TPP), and pH values. In the optimal condition, CD/CS nanoparticles were obtained in the size range of 215-276 nm and with the zeta potential from 30.22 mV to 35.79 mV. Moreover, the stability study showed that the incorporation of CD rendered the CD/CS nanocarriers more stable than CS nanoparticles in PBS buffer at pH 6.8. For their easy preparation and adjustable parameters in nanoparticle formation as well as the diversified hydrophobic core of CD derivatives, the novel CD/CS nanoparticles developed herein might represent an interesting and versatile drug delivery platform for a variety of poorly water-soluble drugs with different physicochemical properties. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.