文献类型：期刊文献

英文题名：Improvement of bioactivity, degradability, and cytocompatibility of biocement by addition of mesoporous magnesium silicate into sodium-magnesium phosphate cement

作者：Wu, Yingyang[1];Tang, Xiaofeng[1];Chen, Jie[1];Tang, Tingting[2];Guo, Han[3];Tang, Songchao[1];Zhao, Liming[1];Ma, Xuhui[4];Hong, Hua[1];Wei, Jie[1]

机构：[1]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Shanghai Key Lab Orthopaed Implants, Sch Med, Dept Orthopaed Surg,Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China;[4]Polymer Sci Shenzhen New Mat Co Ltd, Shenzhen 518101, Peoples R China

年份：2015

卷号：26

期号：9

外文期刊名：JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

收录：;EI(收录号：20154001324312);WOS:【SCI-EXPANDED(收录号:WOS:000361756500011)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (31271031, 51173041), the International Cooperation Project of the Ministry of Science and Technology of China (2013DFB50280), the National High Technology Research & Development Program of China (863 Program) (2014AA021202), the Major International Joint Research Project between China and Korea (81461148033, 31311140253) and Special Program of Strategic Emerging Industries Development of Shenzhen (CXZZ2012070355537097).

语种：英文

外文关键词：Water absorption - Magnesia - Sodium compounds - Mesoporous materials - Cell culture - Phosphatases - Compressive strength - Silicates

摘要：A novel mesoporous magnesium-based cement (MBC) was fabricated by using the mixed powders of magnesium oxide, sodium dihydrogen phosphate, and mesoporous magnesium silicate (m-MS). The results indicate that the setting time and water absorption of the MBC increased as a function of increasing m-MS content, while compressive strength decreased. In addition, the degradability of the MBC in a solution of Tris-HCl and the ability of apatite formation on the MBC were significantly improved with the increase in m-MS content. In cell culture experiments, the results show that the attachment, proliferation, and alkaline phosphatase activity of the MC3T3-E1 cells on the MBC were significantly enhanced with the increase of the content of m-MS. It can be suggested that the MBC with good cytocompatibility could promote the proliferation and differentiation of the MC3T3-E1 cells. In short, our findings indicate that the MBC containing m-MS had promising potential as a new biocement for bone regeneration and repair applications.