文献类型：期刊文献

英文题名：Solubility and permeation enhancement of poor soluble drug by cholinium-amino acid based ionic liquids

作者：Yuan, Jing[1];Wu, Jieyu[2];Yin, Tianxiang[2]

机构：[1]Shanghai Sixth Peoples Hosp East, Shanghai 201306, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：60

外文期刊名：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000601018900003)】；

基金：This work was supported by the National Natural Science Foundation of China (Projects 21773063, and 21303055). The author Jing Yuan also thanks for the financial support from the scientific research project in Shanghai Sixth People's Hospital East.

语种：英文

外文关键词：Ionic liquids; Transdermal drug delivery; Solubility increase; Permeation enhancer

摘要：Ionic liquids have recently been found to be effective ingredient in formulation of transdermal drug delivery system. In this work, we synthesized two cholinium-animo acid based ionic liquids CHAAILs, cholinium glycinate [Ch][Gly] and cholinium analinate [Ch][Ala], and investigated their ability to enhance the solubility and permeation of model drug ibuprofen. The solubility measurements showed that slight amount of CHAAILs can significantly increase the solubility of ibuprofen. Besides, the effective enhancement of permeation of ibuprofen across polyethersulfone (PES) membrane was clearly presented at low concentration (0.8 wt%) of CHAAILs. It is more valuable that the addition of CHAAILs brings little cytotoxicity. Therefore, [Ch][Gly] and [Ch][Ala] can be served as green and effective constituents in transdermal drug delivery system.