文献类型：期刊文献

英文题名：A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

作者：Rui, Leilei[1];Xue, Yudong[1];Wang, Yong[2];Gao, Yun[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Nanjing Tech Univ, Coll Chem & Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China

年份：2017

卷号：53

期号：21

起止页码：3126

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000398998000031)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21574039 and 51173044), and the State Key Laboratory of Materials-Oriented Chemical Engineering (KL14-03).

语种：英文

摘要：A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host-guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (O-1(2)) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.