文献类型：期刊文献

英文题名：A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate

作者：Lei, Min[2];Ma, Lei[1];Hu, Lihong[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2011

卷号：52

期号：20

起止页码：2597

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000291332500019)，CCR-EXPANDED(收录号:WOS:000291332500019)】；

基金：This work was supported by the Chinese National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program' (Grants 2009ZX09301-001, 2009ZX09102-022), the National Natural Science Foundation of China (Grants 21002027, 90713046, 30772638 and 30925040), and CAS Foundation (Grant KSCX2-YW-R-179).

语种：英文

外文关键词：Green chemistry; Multi-component reaction; 4-Hydroxyquinolin-2(1H)-one; Aldehyde; Malononitrile

摘要：A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives has been developed by one-pot condensation of 4-hydroxyquinolin-2(1H)-one, aldehyde, and malononitrile in the presence of ammonium acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reaction time, and little environmental impact. (C) 2011 Elsevier Ltd. All rights reserved.