文献类型：期刊文献

英文题名：Lewis-Acid-Catalyzed Benzylic Reactions of 2-Methylazaarenes with Aldehydes

作者：Mao, Dan[1,2];Hong, Gang[1,2];Wu, Shengying[1,2];Liu, Xin[1,2];Yu, Jianjun[1,2];Wang, Limin[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：2014

期号：14

起止页码：3009

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000335582100019)】；

基金：This research was financially supported by the National Nature Science Foundation of China (NSFC) (grant numbers 21272069, 20672035) and the Fundamental Research Funds for the Central Universities and Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.

语种：英文

外文关键词：Nitrogen heterocycles; Aldol reactions; C-H activation

摘要：Lewis-acid-catalyzed benzylic reactions of 2-methylazaarenes with aldehydes have been investigated. Series of azaarene derivatives were afforded by this reaction. 2-(Pyridin-2-yl)ethanols with common substituents were formed through the LiNTf2-promoted aldol reaction for the first time. 2-Alkenylpyridines, exclusively in the form of the E isomers, were synthesized in the presence of LiNTf2 cooperated with H2NTf. In the presence of La(Pfb)(3) as catalysis, 2-alkenylquinolines were obtained in high yields through the reactions between 2-methylquinolines and aldehydes under air.