文献类型：期刊文献

英文题名：Open-vessel Synthesis of Poly-N-methoxyethylglycine

作者：Liu, Guojian[1,2];Ma, Ke[1,2];Chen, Qi[1,2];Zhang, Donghui[1,3];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat,Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Shanghai 200237, Peoples R China

年份：2024

卷号：40

期号：1

起止页码：153

外文期刊名：CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001152419600003)】；

基金：This work was supported by the National Key Research and Development Program of China (No. 2022YFC2303100), the National Natural Science Foundation of China (Nos. 22075078, 22205063), the Shanghai Sailing Program, China (No. 22YF1410100) and the Fund of the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), China. The authors also thank the Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

外文关键词：Open-vessel; Polypeptoid synthesis; Poly-N-methoxyethylglycine; Stable monomer; Narrow dispersity

摘要：Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability. One type of polypeptoids, poly-N-methoxyethylglycine (P-Nmeg), has been found to possess remarkable hydrophilicity and notable properties in terms of protein, cell, and bacterial antifouling. However, the currently known synthesis methods of P-Nmeg include solid-phase synthesis, which is time-consuming and difficult to scale up, and N-substituted N-carboxyanhydride (NNCA) ring-opening polymerization, whose monomers were difficult to store. In this study, we used the chemical stable Nmeg N-phenoxycarbonyl (NPC) as the monomer, which was obtained without the use of highly toxic reactants, such as phosgene or phosphorus halide, to synthesize P-Nmeg under open-vessel conditions. By adding BnNH2 as an initiator at 80 degree celsius, we can obtain controllable short chain length P-Nmeg with narrow dispersity.