文献类型：期刊文献

英文题名：Molecularly engineered AIEgens with enhanced quantum and singlet-oxygen yield for mitochondria-targeted imaging and photodynamic therapy

作者：Xu, Fang-Zhou[1];Zhu, Ling[1];Han, Hai-Hao[1,3];Zou, Jian-Wei[2];Zang, Yi[3];Li, Jia[3,4,7];James, Tony D.[5,6];He, Xiao-Peng[1];Wang, Cheng-Yun[1]

机构：[1]East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr,Key L, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, Shanghai 200237, Peoples R China;[2]NingboTech Univ, Ningbo 315100, Zhejiang, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China;[4]Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China;[5]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[6]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China;[7]Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China

年份：2022

卷号：13

期号：32

起止页码：9373

外文期刊名：CHEMICAL SCIENCE

收录：;EI(收录号：20223212554000);WOS:【SCI-EXPANDED(收录号:WOS:000835919800001)】；

基金：X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201) and the Shanghai Science and Technology Committee (No. 19410712600). C.-Y. W. is grateful for.nancial support from Natural Science Foundation of Shanghai (No. 22ZR1417300). H.-H. H. thanks the National Natural Science Foundation of China (No. 22107029) and Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

语种：英文

外文关键词：Cancer cells - Charge transfer - Fluorescence - Locks (fasteners) - Mitochondria - Oxygen - Photodynamic therapy

摘要：Luminogens characteristic of aggregation-induced emission (AIEgens) have been extensively exploited for the development of imaging-guided photodynamic therapeutic (PDT) agents. However, intramolecular rotation of donor-acceptor (D-A) type AIEgens favors non-radiative decay of photonic energy which results in unsatisfactory fluorescence quantum and singlet oxygen yields. To address this issue, we developed several molecularly engineered AIEgens with partially "locked" molecular structures enhancing both fluorescence emission and the production of triplet excitons. A triphenylphosphine group was introduced to form a D-A conjugate, improving water solubility and the capacity for mitochondrial localization of the resulting probes. Experimental and theoretical analyses suggest that the much higher quantum and singlet oxygen yield of a structurally "significantly-locked" probe (LOCK-2) than its "partially locked" (LOCK-1) and "unlocked" equivalent (LOCK-0) is a result of suppressed AIE and twisted intramolecular charge transfer. LOCK-2 was also used for the mitochondrial-targeting, fluorescence image-guided PDT of liver cancer cells.