文献类型：期刊文献

英文题名：Efficient Determination of Trace Thionyl Chloride in the Antiepileptic Levetiracetam by Pyrolysis Combined with Ion Chromatography

作者：Luan, Shaorong[1];Liu, Pengyu[1];Zhang, Fangfang[3];Ni, Lijun[1];Huang, Qingchun[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Thermo Fisher Sci China Co Ltd, Shanghai 201203, Peoples R China

年份：2020

卷号：83

期号：11

起止页码：1391

外文期刊名：CHROMATOGRAPHIA

收录：;EI(收录号：20242616382440);WOS:【SCI-EXPANDED(收录号:WOS:000570814000001)】；

基金：This work was supported by the Project of Shanghai Science and Technology Innovation Action Plan in China (NO. 19391902400).

语种：英文

外文关键词：Thionyl chloride; Levetiracetam; Pyrolysis; Ion chromatography

摘要：A method involving pyrolysis pretreatment followed by ion chromatography was developed to determine the residual thionyl chloride in levetiracetam. Levetiracetam was combusted at high temperature. After the pyrolysis gas was absorbed, the sulfur in thionyl chloride was converted to sulfate, which were determined by ion chromatography with conductivity detector using potassium hydroxide as the mobile phase. The linearity, limits of detection and quantification, and recovery of the method were evaluated. The average rate of conversion of thionyl chloride to sulfate was 98.2%, indicating good conversion efficiency. The limit of detection for sulfate was 8.85 mu g/L. The relative standard deviation of the amount of SOCl(2)calculated based on the concentration of sulfate was 2.70%, indicating good repeatability. The recovery for sulfate was 96.0-104%. The results suggest that pyrolysis combined with ion chromatography is an effective method to determine residual thionyl chloride in levetiracetam.