文献类型：期刊文献

英文题名：Fast setting and anti-washout injectable calcium-magnesium phosphate cement for minimally invasive treatment of bone defects

作者：Chen, Fangping[1,2,3];Song, Zhiyan[3];Liu, Changsheng[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：3

期号：47

起止页码：9173

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20154901638425);WOS:【SCI-EXPANDED(收录号:WOS:000365532000011)】；

基金：This investigation was supported by the National Basic Research Program of China (973 Program: 2012CB933600), National Natural Science Foundation of China (No. 31370960, No. 31100678), National Science and Technology Pillar Program during the Twelfth Five-years Plan Period (No. 2012BAD32B01), the 111 Project (B14018), Program of Shanghai Leading Academic Discipline Project (No. B502), and National Special Fund for State Key Laboratory of Bioreactor Engineering (No. 2060204).

语种：英文

外文关键词：Calcium phosphate - Bone - Magnesium compounds - Compressive strength - Biodegradability - Bone cement - Cements - Setting

摘要：The development of injectable calcium phosphate cements (ICPC) represents a promising approach for minimally invasive surgical techniques. However, the undesirable anti-washout property and slow setting time of ICPC greatly hinder its clinical application. Xanthan gum (XG) has strong hydrophilic, shape retention and rheological properties. In this study, a fast setting and anti-washout injectable calcium-magnesium phosphate cement (fa-ICMPC) was developed by introducing XG, as an anti-washout agent, and magnesium phosphate cement (MPC) into calcium phosphate cement (CPC). The bone-regenerative capacity and the bioresorption of the fa-ICMPC were also investigated by injecting it directly into a rabbit thigh bone defect. The result showed that XG imparted anti-washout properties to the fa-ICMPC and enhanced the injectability of the fa-ICMPC. With the protection of thick viscous films formed by XG, the setting of the fa-ICMPC was not disturbed but accelerated due to the synergistic effect of MPC. The result demonstrated that fa-ICMPC was not crumbled and could fill the defects tightly. The newly-formed bone tissue grew into fa-ICMPC along with the degradation of the materials. In short, the fa-ICMPC exhibited potent anti-washout properties, fast setting, improved injectability, good biodegradability and osteoconductivity, and has the potential to repair bone defects by minimal invasive treatment.