文献类型：期刊文献

英文题名：Long Circulating Polymeric Nanoparticles for Gene/Drug Delivery

作者：Hu, Jiaming[2];Sheng, Yan[1];Shi, Junfeng[2];Yu, Bohao[3];Yu, Zhiqiang[4];Liao, Guochao[5]

机构：[1]Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China;[2]Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[4]Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China;[5]Guangzhou Univ Chinese Med, Int Inst Translat Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

年份：2018

卷号：19

期号：9

起止页码：723

外文期刊名：CURRENT DRUG METABOLISM

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000443160500002)】；

基金：The authors wish to express their gratitude to the financial supports from National Natural Science Foundation of China (No. 31300789) and Natural Science Foundation of Shandong Province (No. ZR2013CQ016).

语种：英文

外文关键词：Long circulation; biodistribution; opsonization; mononuclear phagocyte system; polymeric nanoparticles; gene/drug delivery

摘要：Background: The prolonged circulation time of nanoparticles in the blood is a prerequisite to realize a controlled and targeted (passive or active targeting) release of the encapsulated gene/drug at the desired site of action. The most popular method to mask or camouflage nanoparticles is the adsorbed, grafted or conjugated of poly (ethylene glycol) (PEG) or other hydrophilic polymers (e.g. polysaccharides) to the particle surface. However, the circulation half-life of nanoparticles still cannot satisfy the need of clinical use. Method: This review focuses on several recent advances in the design and fabrication of polymeric nanoparticles with long circulating characters in blood. The factors influencing the physicochemical characteristics of nanoparticle surface and its surface modification have been discussed. Results: Gene/drug carriers can also be combined with functionalized physical, chemical or biological stimuli to improve passive and active targeting strategies. The choice of suitable manufacturing technique of polymeric nanoparticles depends on the gene/drug to be encapsulated in the particle, the physicochemical properties of the polymer, their therapeutic goal to be reached and the scalability of the fabrication which allows for a clinical realization of the most promising nanomedicines. The factors influencing long circulating properties of nanoparticles are mainly particle size, surface charge and hydrophilicity. Surface modification of polymeric nanoparticles has been focused on PEG, polysaccharides, and so on. Conclusion: Identification of novel potential coating materials with satisfied characters is an emerging field of interest in the design of long circulating polymer-based nanoparticulate gene/drug delivery.