文献类型：期刊文献

英文题名：Engineering a photoswitchable acaricidal agent by the integration of an azobenzene moiety with a bifenazate structure

作者：Zhang, Yongchao[1];Qiao, Zhi[2];Liu, Zimai[1];Yin, Qi[1];Li, Xiaoyan[3];Li, Zhong[1,4];Fu, Wen[1,5];Shao, Xusheng[1,4,6,7]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Yantai Lannacheng Biotechnol Co Ltd, Yantai, Shandong, Peoples R China;[3]China Agr Univ, Coll Humanities & Econ Management, Yantai Inst, Yantai, Shandong, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[5]Guizhou Univ, Natl Key Lab Green Pesticide, Guiyang, Guizhou, Peoples R China;[6]East China Univ Sci & Technol, Sch Pharm, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai, Peoples R China;[7]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai, Peoples R China

年份：2026

外文期刊名：PHOTOCHEMISTRY AND PHOTOBIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001661076700001)】；

基金：National Natural Science Foundation of China, Grant/Award Number: 32402439, 32472610 and 32072441; National Key Research and Development Program of China, Grant/Award Number: 2018YFD0200100; Innovation Program of Shanghai Municipal Education Commission, Grant/Award Number: 2017-01-07-00-02-E00037; Tobacco and Health funding program, Grant/Award Number: 2022539200340111; Project of National Key Laboratory of Green Pesticide/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Grant/Award Number: SKL-GPL-KF-202405; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission)

语种：英文

外文关键词：azobenzene; bifenazate; photochromic ligands; photopharmacology

摘要：Photopharmacology achieves precise photo controlled regulation of drug activity by utilizing the properties of photochromic ligands. In this study, a series of novel azobenzene-based photochromic ligands (ABB1-5) were designed and synthesized, and their biological activities were confirmed to be precisely regulated by light irradiation. Bioassays against larvae of Culex pipiens pallens showed that the activity of ABB1 was significantly enhanced after light exposure, with the median lethal concentration (LC50) decreasing from 27.20 mu g/mL before irradiation to 16.99 mu g/mL after, a reduction of 10.21 mu g/mL, yielding a difference coefficient of 1.60. Similarly, experiments on Tetranychus cinnabarinus demonstrated a remarkable decrease in acaricidal activity for ABB4 after irradiation, as evidenced by an increase in LC50 from 7.01 to 18.40 mu g/mL, an increase of 11.39 mu g/mL, with a difference coefficient of 2.62. Notably, the light-induced differences in activity exhibited by the ABBs series against both C. pipiens pallens larvae and T. cinnabarinus not only validate the potential of photochromic ligands in the precise optical control of drug efficacy but also offer a novel strategy for delaying the development of resistance to acaricides in phytophagous mites.