文献类型：期刊文献

中文题名：Biomarkers of aging

英文题名：Biomarkers of aging

作者：Aging Biomarker Consortium[1];Bao, Hainan[2,3];Cao, Jiani[4];Chen, Mengting[5,6,7];Chen, Min[8,9,10];Chen, Wei[11];Chen, Xiao[12];Chen, Yanhao[13];Chen, Yu[14];Chen, Yutian[15];Chen, Zhiyang[16];Chhetri, Jagadish K.[17];Ding, Yingjie[2,3,18];Feng, Junlin[19];Guo, Jun[20];Guo, Mengmeng[21];He, Chuting[18,22,23,24];Jia, Yujuan[25];Jiang, Haiping[4,18,23,24];Jing, Ying[26,27,28,29];Li, Dingfeng[30];Li, Jiaming[2,3,18];Li, Jingyi[18,22,23,24];Liang, Qinhao[31];Liang, Rui[32];Liu, Xiaoqian[4,18,23,24];Liu, Zuojun[34];Luo, Oscar Junhong[35];Lv, Jianwei[36];Ma, Jingyi[37];Mao, Kehang[38];Nie, Jiawei[39];Qiao, Xinhua[40];Sun, Xinpei[41];Tang, Xiaoqiang[42];Wang, Jianfang[43];Wang, Qiaoran[2,3,18];Wang, Siyuan[44];Wang, Xuan[45];Wang, Yaning[46,47];Wang, Yuhan[18,22,23,24];Wu, Rimo[48];Xia, Kai[49,50];Xiao, Fu-Hui[51,52];Xu, Lingyan[53,54];Xu, Yingying[2,3];Yan, Haoteng[26,27,28,29];Yang, Liang[55,56,57];Yang, Ruici[58];Yang, Yuanxin[59];Ying, Yilin[60,61];Zhang, Le[62,63];Zhang, Weiwei[64];Zhang, Wenwan[19];Zhang, Xing[65];Zhang, Zhuo[66,67];Zhou, Min[68];Zhou, Rui[69,70];Zhu, Qingchen[19];Zhu, Zhengmao[71,72];Cao, Feng[64];Cao, Zhongwei[73];Chan, Piu[17];Chen, Chang[40];Chen, Guobing[74,75];Chen, Hou-Zao[76];Chen, Jun[77];Ci, Weimin[2,3];Ding, Bi-Sen[73];Ding, Qiurong[13];Gao, Feng[65];Han, Jing-Dong J.[38];Huang, Kai[8,9,10,78];Ju, Zhenyu[16];Kong, Qing-Peng[51,52];Li, Ji[5,6,7];Li, Jian[20];Li, Xin[4,18,23,24];Liu, Baohua[79];Liu, Feng[33,80];Liu, Lin[71,72,81,82];Liu, Qiang[30,83,84];Liu, Xingguo[55,56,57];Liu, Yong[31];Luo, Xianghang[68];Ma, Shuai[18,22,23,24];Ma, Xinran[53,54];Mao, Zhiyong[14];Nie, Jing[37];Peng, Yaojin[4,18,24];Qu, Jing[4,18,23,24];Ren, Jie[2,3,18,23];Ren, Ruibao[39,85];Song, Moshi[18,22,23,24];Zhou Songyang[33,86];Sun, Yi Eve[11];Sun, Yu[19,87,88];Tian, Mei[89];Wang, Shusen[32];Wang, Si[26,27,28,29];Wang, Xia[21];Wang, Xiaoning[90];Wang, Yan-Jiang[91];Wang, Yunfang[45];Wong, Catherine C. L.[44];Xiang, Andy Peng[49,50];Xiao, Yichuan[19];Xie, Zhengwei[41,92];Xu, Daichao[59];Ye, Jing[60,61];Yue, Rui[43];Zhang, Cuntai[62,63];Zhang, Hongbo[46,47];Zhang, Liang[19,23];Zhang, Weiqi[2,3,18,23];Zhang, Yong[48,93,94];Zhang, Yun-Wu[95];Zhang, Zhuohua[96,97,98];Zhao, Tongbiao[4,18,23,24];Zhao, Yuzheng[66,67];Zhu, Dahai[48,93,94];Zou, Weiguo[58];Pei, Gang[99];Liu, Guang-Hui[18,22,23,24,28,29]

机构：[1]Aging Biomarker Consortium ABC, Beijing 100101, Peoples R China;[2]Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genom & Precis Med, Beijing 100101, Peoples R China;[3]China Natl Ctr Bioinformat, Beijing 100101, Peoples R China;[4]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing 100101, Peoples R China;[5]Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha 410008, Peoples R China;[6]Cent South Univ, Xiangya Hosp, Hunan Key Lab Aging Biol, Changsha 410008, Peoples R China;[7]Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Peoples R China;[8]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan 430022, Peoples R China;[9]Huazhong Univ Sci & Technol, Hubei Clin Res Ctr Metab & Cardiovasc Dis, Wuhan 430022, Peoples R China;[10]Huazhong Univ Sci & Technol, Hubei Key Lab Metab Abnormal & Vasc Aging, Wuhan 430022, Peoples R China;[11]Tongji Univ, Tongji Hosp, Stem Cell Translat Res Ctr, Sch Med, Shanghai 200065, Peoples R China;[12]Third Mil Med Univ, Daping Hosp, Dept Nucl Med, Chongqing 400042, Peoples R China;[13]Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai 200031, Peoples R China;[14]Tongji Univ, Clin & Translat Res Ctr Shanghai Matern & Infant, Shanghai Key Lab Maternal Fetal Med,Sch Life Sci, Frontier Sci Ctr Stem Cell Res,Shanghai Key Lab S, Shanghai 200092, Peoples R China;[15]Zhengzhou Univ, Dept Endovasc Surg, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China;[16]Jinan Univ, Inst Ageing & Regenerat Med, Key Lab Regenerat Med, Minist Educ, Guangzhou 510632, Peoples R China;[17]Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100053, Peoples R China;[18]Univ Chinese Acad Sci, Beijing 100049, Peoples R China;[19]Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai 200031, Peoples R China;[20]Chinese Acad Med Sci, Beijing Inst Geriatr, Inst Geriatr Med,Key Lab Geriatr, Beijing Hosp,Natl Ctr Gerontol Natl Hlth Commiss, Beijing 100730, Peoples R China;[21]Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China;[22]Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China;[23]Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China;[24]Beijing Inst Stem Cell & Regenerat Med, Beijing 100101, Peoples R China;[25]Shanxi Med Univ, Affiliated Hosp 1, Dept Neurol, Taiyuan 030001, Peoples R China;[26]Capital Med Univ, Beijing Municipal Geriatr Med Res Ctr, Xuanwu Hosp, Beijing 100053, Peoples R China;[27]Capital Med Univ, Xuanwu Hosp, Aging Translat Med Ctr, Int Ctr Aging & Canc, Beijing 100053, Peoples R China;[28]Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Xuanwu Hosp, Beijing 100053, Peoples R China;[29]Capital Med Univ, Natl Clin Res Ctr Geriatr Disorders, Xuanwu Hosp, Beijing 100053, Peoples R China;[30]Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Dep Neurol, Hefei 230036, Peoples R China;[31]Wuhan Univ, TaiKang Ctr Life & Med Sci, Coll Life Sci, Wuhan 430072, Peoples R China;[32]Nankai Univ, Tianjin Cent Hosp 1, NHC Key Lab Crit Care Med, Organ Transplant Ctr,Res Inst Transplant Med, Tianjin 300384, Peoples R China;[33]Sun Yat Sen Univ, Guangzhou Key Lab Healthy Aging Res, MOE Key Lab Gene Funct & Regulat, Sch Life Sci,Inst Hlth Aging Res, Guangzhou 510275, Peoples R China;[34]Hainan Univ, Sch Life Sci, Haikou 570228, Hainan, Peoples R China;[35]Jinan Univ, Sch Med, Dept Syst Biomed Sci, Guangzhou 510632, Peoples R China;[36]Xiamen Univ, Sch Life Sci, Xiamen 361102, Peoples R China;[37]Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res, Natl Clin Res Ctr Kidney Dis,Div Nephrol, Guangzhou 510515, Peoples R China;[38]Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Ctr Quantitat Biol CQB, Beijing 100871, Peoples R China;[39]Shanghai Jiao Tong Univ, Int Ctr Aging & Canc,Shanghai Inst Hematol,Collab, State Key Lab Med Gen,Natl Res Ctr Translat Med S, Collaborat Innovat Ctr Hematol,Ruijin Hosp,Sch Me, Shanghai 200025, Peoples R China;[40]Chinese Acad Sci, Inst Biophys, CAS Ctr Excellence Biomacromol, Natl Lab Biomacromol, Beijing 100101, Peoples R China;[41]Peking Univ, Peking Univ Int Canc Inst, Hlth Sci Ctr, Beijing 100101, Peoples R China;[42]Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;[43]Tongji Univ, Inst Regenerat Med, Shanghai Key Lab Signaling & Dis Res,Sch Life Sci, Frontier Sci Ctr Stem Cell Res,Shanghai East Hosp, Shanghai 200092, Peoples R China;[44]Chinese Acad Med Sci & Peking Union Med Coll, Clin Res Inst, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China;[45]Beijing Tsinghua Changgung Hosp, Hepatobiliary & Pancreat Ctr, Med Res Ctr, Beijing 102218, Peoples R China;[46]Sun Yat Sen Univ, Zhongshan Sch Med, Key Lab Stem Cells & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China;[47]Sun Yat Sen Univ, Zhongshan Sch Med, Affiliated Hosp 1, Adv Med Technol Ctr, Guangzhou 510080, Peoples R China;[48]Bioland Lab Guangzhou Regenerat Med & Hlth Guangd, Guangzhou 510005, Peoples R China;[49]Sun Yat Sen Univ, Key Lab Stem Cells & Tissue Engn, Ctr Stem Cell Biol & Tissue Engn, Minist Educ, Guangzhou 510080, Peoples R China;[50]Sun Yat Sen Univ, Zhongshan Sch Med, Natl Local Joint Engn Res Ctr Stem Cells & Regene, Guangzhou 510080, Peoples R China;[51]Chinese Acad Sci, CAS Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China;[52]Chinese Acad Sci, Kunming Key Lab Hlthy Aging Study, State Key Lab Genet Resources & Evolut,KIZ CUHK J, Key Lab Hlth Aging Res Yunnan Prov,Kunming Inst Z, Kunming 650223, Yunnan, Peoples R China;[53]East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China;[54]East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China;[55]Chinese Acad Sci, Guangzhou Inst Biomed, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou 510530, Peoples R China;[56]Chinese Acad Sci, Guangzhou Inst Hlth, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou 510530, Peoples R China;[57]Guangzhou Med Univ, Guangzhou 510530, Peoples R China;[58]Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Chinese Acad Sci, State Key Lab Cell Biol,Ctr Excellence Mol Cell S, Shanghai 200031, Peoples R China;[59]Chinese Acad Sci, Shanghai Inst Organ Chem, Interdisciplinary Res Ctr Biol & Chem, Shanghai 201210, Peoples R China;[60]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Geriatr, Med Ctr Aging Shanghai,Sch Med, Shanghai 200025, Peoples R China;[61]Shanghai Jiao Tong Univ, Int Lab Hematol & Canc, Sch Med, Ruijin Hosp, Shanghai 200025, Peoples R China;[62]Gerontol Ctr Hubei Prov, Wuhan 430000, Peoples R China;[63]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Inst Gerontol,Tongji Med Coll, Wuhan 430030, Peoples R China;[64]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Cardiol, Beijing 100853, Peoples R China;[65]Fourth Mil Med Univ, Sch Aerosp Med, Key Lab Minist Educ, Xian 710032, Peoples R China;[66]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Techn Cell M, Optogenet & Synthet Biol Interdisciplinary Res Ct, Sch Pharm,State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[67]Chinese Acad Med Sci, Res Unit New Tech Live Cell Metab Imaging, Beijing 100730, Peoples R China;[68]Cent South Univ, Endocrinol Res Ctr, Dept Endocrinol, Xiangya Hosp, Changsha 410008, Peoples R China;[69]Zhejiang Univ, Dept Nucl Med, Sch Med, Affiliated Hosp 2, Hangzhou 310009, Peoples R China;[70]Zhejiang Univ, PET Ctr, Sch Med, Affiliated Hosp 2, Hangzhou 310009, Peoples R China;[71]Nankai Univ, Coll Life Sci, Dept Genet & Cell Biol, Tianjin 300071, Peoples R China;[72]Chinese Acad Med Sci & Peking Union Med Coll, Haihe Lab Cell Ecosyst, Tianjin 300020, Peoples R China;[73]Sichuan Univ, West China Univ Hosp 2, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;[74]Jinan Univ, Sch Med, Dept Microbiol & Immunol, Guangzhou 510632, Peoples R China;[75]Guangdong Hong Kong Macau Great Bay Area Gerosci, Guangzhou 510000, Peoples R China;[76]Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, State Key Lab Med Mol Biol, Dept Biochem & Mol Biol, Beijing 100005, Peoples R China;[77]Peking Univ, Beijing Key Lab Prot Posttranslat Modificat & Cel, Dept Integrat Chinese & Western Med,Peking Univ R, Dept Biochem & Mol Biol,Sch Basic Med Sci, Beijing 100191, Peoples R China;[78]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430022, Peoples R China;[79]Shenzhen Univ Med Sch, Sch Basic Med Sci, Shenzhen 518060, Peoples R China;[80]Cent South Unvers, Xiangya Hosp 2, Metab Syndrome Res Ctr, Changsha 410011, Peoples R China;[81]Nankai Univ, Tianjin Union Med Ctr, Inst Translat Med, Tianjin 300000, Peoples R China;[82]Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China;[83]Tianjin Med Univ, Tianjin Neurol Inst, Dept Neurol, Gen Hosp, Tianjin 300052, Peoples R China;[84]Tianjin Med Univ, Tianjin Inst Immunol, Tianjin 300070, Peoples R China;[85]Hainan Med Univ, Int Ctr Aging & Canc, Haikou 571199, Hainan, Peoples R China;[86]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510120, Peoples R China;[87]Univ Washington, Dept Med, Seattle, WA 98195 USA;[88]Univ Washington, VAPSHCS, Seattle, WA 98195 USA;[89]Fudan Univ, Human Phenome Inst, Shanghai 201203, Peoples R China;[90]Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Aging & Geriatr, Inst Geriatr, Natl Clin Res Ctr Geriatr Dis,Med Ctr 2, Beijing 100853, Peoples R China;[91]Third Mil Med Univ, Daping Hosp, Dept Neurol & Ctr Clin Neurosci, Chongqing 400042, Peoples R China;[92]Beijing Gigaceuticals Tech Co Ltd, Beijing & Qingdao Langu Pharmaceut R&D Platform, Beijing 100101, Peoples R China;[93]Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China;[94]Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China;[95]Xiamen Univ, Inst Neurosci, Sch Med, Fujian Prov Key Lab Neurodegenerat Dis & Aging Re, Xiamen 361102, Peoples R China;[96]Cent South Univ, Inst Mol Precis Med, Xiangya Hosp, Key Lab Mol Precis Med Hunan Prov, Changsha 410078, Peoples R China;[97]Cent South Univ, Inst Mol Precis Med, Xiangya Hosp, Ctr Med Genet, Changsha 410078, Peoples R China;[98]Univ South China, Hengyang Med Sch, Dept Neurosci, Hengyang 421001, Peoples R China;[99]Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Lab Receptor Based Biomed, Collaborat Innovat Ctr Brain Sci,Sch Life Sci & T, Shanghai 200070, Peoples R China

年份：2023

卷号：66

期号：5

中文期刊名：Science China(Life Sciences)

外文期刊名：SCIENCE CHINA-LIFE SCIENCES

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000991990100001)】；CSCD:【CSCD2023_2024】；PubMed;

基金：Due to space constraints, it is unavoidable that certain important works on aging biomarkers are not cited, and we offer our sincere apologies. We would like to express our sincerest gratitude to the members of the expert panel of the Major Program on Organ Aging and Degeneration. We thank all the members of the Aging Biomarker Consortium for their valuable input and suggestions. This work was supported by the National Natural Science Foundation of China (31730036, 31871380, 31871382, 31930055, 31930058, 32000500, 32022034, 32030033, 32070730, 32130046, 3217050247, 32150005, 32200595, 32222024, 81730019, 81730022, 81830014, 81921006, 81925005, 81970426, 81971301, 81971312, 82030041, 82061160495, 82070805, 82071595, 82090020, 82100841, 82120108009, 82122024, 82125002, 82125011, 82125012, 82130045, 82171284, 82173061, 82173398, 82225007, 82225015, 82225017, 82225018, 82230047, 82230088, 82271600, 91949106, 91949201, 92049116, 92049302, 92049304, 92149303, 92149306, 92157202, 92168201, 92169102, 92249301, 92268201), the National Key Research and Development Program of China (2018YFA0800700, 2018YFC2000100, 2018YFC2000102, 2018YFC2002003, 2019YFA0110900, 2019YFA0801703, 2019YFA0801903, 2019YFA0802202, 2019YFA0904800, 2020YFA0113400, 2020YFA0803401, 2020YFA0804000, 2020YFC2002900, 2020YFC2008000, 2020YFE0202200, 2021YFA0804900, 2021YFA1100103, 2021YFA1100900, 2021YFE0114200, 2021ZD0202400, 2022YFA0806001, 2022YFA0806002, 2022YFA0806600, 2022YFA1103200, 2022YFA1103601, 2022YFA1103701, 2022YFA1103800, 2022YFA1103801, 2022YFA1104100, 2022YFA1104904, 2022YFA1303000, 2022YFC2009900, 2022YFC2502401, 2022YFC3602400, 2022YFE0118000, 2022ZD0213200), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16030302, XDB39000000, XDB39030600), the Youth Innovation Promotion Association of Chinese Academy of Sciences (2020085, 2021080), CAS Project for Young Scientists in Basic Research (YSBR-076), the Program of the Beijing Natural Science Foundation (JQ20031), Clinical Research Operating Fund of Central High level hospitals (2022-PUMCH-E-001), CAMS Innovation Fund for Medical Sciences (CIFMS) (2022-I2M-1-004), Talent Program of the Chinese Academy of Medical Science (2022-RC310-10), Research Funds from Health@InnoHK Program launched by Innovation Technology Commission of the Hong Kong Special Administrative Region, Guangdong Basic and Applied Basic Research Foundation (2020B1515020044), Guangzhou Planned Project of Science and Technology (202002020039), the Major Technology Innovation of Hubei Province (2019ACA141), the Science and Technology Major Project of Hunan Provincial Science and Technology Department (2021SK1010), Shanghai Municipal Science and Technology Major Project (2017SHZDZX01), the Natural Science Foundation of Sichuan Province (2023NSFSC0003), Yunnan Fundamental Research Project (202201AS070080) and the State Key Laboratory of Membrane Biology.

语种：英文

中文关键词：aging;senescence;biomarker;clock

外文关键词：aging; senescence; biomarker; clock

摘要：Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant.