文献类型：期刊文献

英文题名：Au-promoted Pd-catalyzed arylative cyclization of N,N-dimethyl-o-alkynylaniline with aryl iodides: Access to 2,3-diaryl indoles and mechanistic insight

作者：Yuan, Kemeng[1,2];Wang, Jiwei[1,2];Wang, Feijun[1,2];Zhang, Jun[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Joint Int Res Lab Precis Chem, Shanghai 200237, Peoples R China

年份：2021

卷号：65

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000615712600020)，CCR-EXPANDED(收录号:WOS:000615712600020)】；

基金：Financial support from the National Natural Science Foundation of China (21171056 and 21671066) is greatly acknowledged.

语种：英文

外文关键词：Indole; Gold catalysis; Palladium catalysis; Heterocycle synthesis; Arylative cyclization

摘要：We have developed a Au-promoted Pd-catalyzed cyclization/cross-coupling of N,N-dimethyl-o-alkynylaniline with aryl iododes to synthesize 2,3-diarylindoles under mild and base-free conditions. A related vinyl-Au species has been isolated through Au-promoted cyclization of N,N-dimethyl-o-alkynylaniline and structurally characterized. Further study on its reactivity suggests the vinyl-Au species might be out of catalytic cycle, and PhPd(OTf)(PPh3)(2) is probably the reaction intermediate. (C) 2020 Published by Elsevier Ltd.