文献类型：期刊文献

英文题名：Argutalactone, an unprecedented sesquiterpenoid lactone with a 6/5/7 tricyclic system from Incarvillea arguta

作者：Fu, Jian-Jun[1,2];Wang, Li-Yan[2];Li, Hong-Lin[2];Qin, Jiang-Jiang[1];Shen, Yun-Heng[3];Cheng, Jia-Gao[2];Jin, Hui-Zi[1];Zhang, Wei-Dong[2,3]

机构：[1]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

年份：2012

卷号：14

期号：5

起止页码：496

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000303568200014)】；

基金：The authors thank Prof. Yue-Kui Wang of Shanxi University for his helpful discussions and suggestions. This work was financially supported by program NCET Foundation, NSFC (30725045 and 20803022), the National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China (2009ZX09311-001, 2008ZX09101-Z-029, 2009ZX09103-375, and 2009ZX09501-001).

语种：英文

外文关键词：Incarvillea arguta; argutalactone; sesquiterpenoid lactone; density functional calculations

摘要：Argutalactone (1), a novel sesquiterpenoid lactone featuring an unprecedented 6/5/7 rigid skeleton, was isolated from the roots of Incarvillea arguta. The structure and relative configuration of 1 were established by extensive analysis of spectroscopic data. The absolute configuration of 1 was determined as 2R, 5S, 10R, 12S based on the analysis of biogenetical transformation, comparison of the optical rotation with literature data, and comparison of the experimental circular dichroism spectrum with the calculated electronic circular dichroism spectra.