文献类型：期刊文献

英文题名：Synergistic effect of a combined live Vibrio anguillarum and Edwardsiella piscicida vaccine in turbot

作者：Bao, Pengcheng[1,2];Sun, Xiang[1,2];Liu, Qin[1,2];Zhang, Yuanxing[1,2];Liu, Xiaohong[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Engn Res Ctr Maricultured Anim Vaccines, Shanghai 200237, Peoples R China

年份：2019

卷号：88

起止页码：84

外文期刊名：FISH & SHELLFISH IMMUNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000465060500010)】；

基金：This work was financially supported by the National Natural Science Foundation of China (31602200 to XL and 31622059 to QL), Shandong Province Key Research and Development Plan (2017CXGC0103) and the Modern Agro-industry Technology Research System (CARS-47).

语种：英文

外文关键词：Combined-vaccination; Vibrio anguillarum; Edwardsiella piscicida; Immune synergy

摘要：In aquaculture, more than one pathogen usually be isolated from the sick fish, creating an urgent need for developing combined vaccines to control fish disease caused by multiple pathogens simultaneously. In our previous work, two live attenuated vaccines against Vibrio anguillarum and Edwardsienn piscicida were vaccinated in turbot, exhibiting an efficient protection. However, some immunological processes such as antigenic competition, antigenic cross-reaction and antigen induced suppression during combined vaccination are unknown. In this study, we evaluated the effectiveness of the combined live vaccines and explored the immunological processes after vaccination. We found that the combined two live attenuated vaccines for V. anguillarum and E. piscicida induced a stronger immune response without existing antigen competition. Instead, a synergistic effect was observed not only for triggering innate immune response but for stimulation of adaptive immunity. Our study suggested that the two combined live vaccines against V. anguillarum and E. piscicida could be used simultaneously in the future.