文献类型：期刊文献

中文题名：硝苯地平在球状活性炭中的吸附及缓释行为

英文题名：Adsorption of nifedipine by spherical activated carbons and their in-vitro release behavior

作者：吕春祥[1];凌立成[2];袁淑霞[1];梁栋[1];李永红[1]

机构：[1]中国科学院炭材料重点实验室中国科学院山西煤炭化学研究所;[2]华东理工大学化工学院,上海200237

年份：2007

卷号：22

期号：1

起止页码：17

中文期刊名：新型炭材料

外文期刊名：New Carbon Materials

收录：CSTPCD;;EI(收录号：20084211647143);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000245636100004)】；北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金(50072036);中国科学院院长基金项目~~

语种：中文

中文关键词：球状活性炭;缓释;硝苯地平

外文关键词：Spherical activated carbons; In-vitro release; Nifedipine

摘要：采用球状活性炭作为硝苯地平药物载体,借助N2吸附仪表征了球状活性炭的比表面积和孔结构,利用SEM表征了球状活性炭的表面形貌,通过考察球状活性炭比表面积、孔隙结构与吸附性能和体外释放性能的关系,研究了球状活性炭对硝苯地平的吸附及缓释行为。结果表明:比表面积大、孔隙结构发达、孔径分布集中在2nm^5nm之间的中孔型活性炭,对硝苯地平的吸附能力较强,吸附量可达19.5mg/g;所制缓释微丸缓释效果良好,在接近人体胃液介质中累计释放率达到19.2%;球状活性炭对硝苯地平的释放动力学符合Higuchi模型,药物基本以恒定速率主动释放。
Adsorption of nifedipine by spherical activated carbons （SACs） and their in-vitro release behavior were investigated. The pore structure, specific surface area and surface morphologies of the SACs were tested by N2 adsorption and SEM. The relationship between pore structure, specific surface area and adsorption/in-vitro release behavior was discussed. Results indicated that SACs with a high specific surface area and abundant mesopores ranging between 2 nm and 5 nm exhibited excellent adsorption and in-vitro release of nifedipine. The maximum adsorption capacity was 19.5 mg/g, and the total release rate can reach 19.20 %. The release dynamics of SACs containing nifedipine are in accordance with the Higuchi model, which shows that the release speed is a constant.