文献类型：期刊文献

英文题名：Microporous surface containing flower-like molybdenum disulfide submicro-spheres of sulfonated polyimide with antibacterial effect and promoting bone regeneration and osteointegration

作者：Kaewmanee, Rames[1];Wang, Fan[1];Pan, Yongkang[1];Mei, Shiqi[1];Meesane, Jirut[2];Li, Fengqian[3];Wu, Zhaoying[4];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Prince Songkla Univ, Fac Med, Inst Biomed Engn, Hat Yai, Thailand;[3]Shanghai Eighth Peoples Hosp, Shanghai 200235, Peoples R China;[4]Sun Yat Sen Univ, Sch Biomed Engn, Shenzhen Campus, Shenzhen 518107, Guangdong, Peoples R China

年份：2022

卷号：10

期号：15

起止页码：4243

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20222812345948);WOS:【SCI-EXPANDED(收录号:WOS:000817729000001)】；

基金：Grants were received from the National Natural Science Foundation of China (32171340), the Shenzhen Fundamental Research Program (JCYJ20190807160811355), the National Science Foundation of Shanghai (21ZR1447900) and the GuangDong Basic and Applied Basic Research Foundation (2021A1515010527).

语种：英文

外文关键词：Bone - Layered semiconductors - Microporosity - Molybdenum disulfide - Polyimides - Surface roughness

摘要：Implanted materials with both osteogenic and antibacterial functions are promising for facilitating osteointegration and preventing infection for orthopedic applications. In this work, we synthesized flower-like molybdenum disulfide (fMD) submicro-spheres containing nanosheets, which were incorporated onto the microporous surface of polyimide (PI) via concentrated sulfuric acid, suspending fMD contents of 5 wt% (SPM1) and 10 wt% (SPM2). Compared with sulfonated polyimide (SPM0), both SPM1 and SPM2 with microporous surfaces containing fMD exhibited nano-submicro-microporous surfaces, which improved the surface roughness, wettability, and surface energy. Due to there being more fMD submicro-spheres on the microporous surface, SPM2 revealed a better antibacterial effect than SPM1. In addition, compared with SPM1 and SPM0, SPM2 with more fMD significantly promoted rat bone marrow-derived stromal cell response in vitro. Moreover, SPM2 remarkably enhanced new bone formation and osteointegration in vivo. In summary, the combination of fMD with the microporous surface of SPM2 resulted in a nano-submicro-microporous surface with optimized surface performance, which possessed not only osteogenic bioactivity but also an antibacterial effect. As a bone implant, SPM2 with osteogenic and antibacterial functions may have enormous potential as a bone tissue substitute.