文献类型：期刊文献

英文题名：Novel paeonol-matrine deep eutectic solvent: Physicochemical properties and cytotoxicity

作者：Wu, Jieyu[1];Yin, Tianxiang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：348

外文期刊名：JOURNAL OF MOLECULAR LIQUIDS

收录：;EI(收录号：20214711217656);WOS:【SCI-EXPANDED(收录号:WOS:000754539500004)】；

基金：This work was supported by the National Natural Science Foundation of China (Projects 21773063).

语种：英文

外文关键词：Viscosity; Refractive index; Surface tension; Inhibitory activity on tyrosinase; Cytotoxicity

摘要：Deep eutectic solvent (DES), as a new type of green solvent, showed great advantages of easy preparation and no need of purification after synthesis and has been widely investigated in various fields. Paeonol has been shown great potential applications due to its anti-inflammatory, antioxidant, and antibacterial functions. In this work, we designed a new DES based on paeonol and matrine with a series molar ratio of 3:7, 4:6, and 5:5. The interactions between matrine and paeonol were checked and verified by (HNMR)-H-1 and FT-IR spectra. Thereafter, the physicochemical properties of DESs were investigated by various techniques in a temperature range from 303.15 K to 343.15 K. It has been shown that the viscosity, surface tension, and refractive index decline with the increasing temperature. DESs showed relatively lower inhibitory activity on tyrosinase as compared with the paeonol at the same concentration as that in DES. Moreover, DESs displayed lower cytotoxicity than that of paeonol. Therefore, this work provided fundamental information for the application of these DESs, which may be considered as potential candidates for transdermal delivery of paeonol. (C) 2021 Elsevier B.V. All rights reserved.