文献类型：期刊文献

英文题名：Biomimetic multi-channel nerve conduits with micro/nanostructures for rapid nerve repair

作者：Wang, Xinqing[2];Chen, Shuo[2];Chen, Xiaolei[2];Wu, Juan[2];Huang, Zhenhua[2];Wang, Jing[1,2];Chen, Fangping[1,2];Liu, Changsheng[1,2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2024

卷号：41

起止页码：577

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001318254000001)】；

基金：This investigation was supported by the National Natural Science Foundation of China (No. 32171342; 51772100) , National Key Research and Development Program of China (2023YFC2413600) . The authors thank ResearchCenter of Analysis and Test of East China University of Science and Technologyfor the help on the characterization.

语种：英文

摘要：Peripheral nervous system (PNS) injuries often lead to significant sensory and motor impairments. Traditional artificial nerve conduits, lacking anisotropic structures, have been associated with prolonged repair time and failures in nerve regeneration. This study aimed to address these challenges by developing a novel approach for rapid repair of peripheral nerve injuries (PNI). A 3D oriented fibers scaffold featuring distinct radial (RFs) and longitudinal (LFs) fibers orientations was engineered using coaxial electrospinning and gas directional foaming techniques. This scaffold was then integrated with a shape memory conduit to form a directional multi-channel nerve conduit with micro/nanostructures. The results revealed that the grooved surface of the fibers significantly improved cellular directional guidance, effectively facilitating the migration of SCs from the periphery towards the center and from the base to the apex of the scaffold. In a rat model with a 10 mm nerve defect, the ND-PLATMC/LF ND-PCL scaffold significantly enhanced nerve regeneration and motor function recovery within 4 weeks. These results suggest the potential of this innovative scaffold for efficient repair of the nerve injuries.