文献类型：期刊文献

英文题名：Spectral and biodistributional engineering of deep near-infrared chromophore

作者：Dong, Yan[1];Lu, Xicun[1];Li, Yi[1];Chen, Weichao[1];Yin, Lei[1];Zhao, Jie[1];Hu, Xinru[1];Li, Xinran[1];Lei, Zuhai[1];Wu, Yuyang[3];Chen, Hao[3];Luo, Xiao[1,2];Qian, Xuhong[1,2];Yang, Youjun[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Mol Imaging Ctr, Shanghai 201203, Peoples R China

年份：2023

卷号：34

期号：9

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001032705700001)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 21908065 , 22078098 , and 22278138) , the Shanghai Academic Technology Research Leader (No. 22XD1421000) , the Research Funds of Happiness Flower ECNU (No. 2020JK2103) , and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：Near infrared fluorophore; In vivo imaging; Molecular engineering; Biological distribution; Angiography

摘要：Fluorescence-guided surgery calls for development of near-infrared fluorophores. Despite the wide-spread application and a safe clinical record of Indocyanine Green (ICG), its maximal absorption wavelength at 780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth. Here, we report ECY , a stable deep near-infrared (NIR) fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16% in CH 2 Cl 2 . ECY was further rationally engineered for biological distribution specificity. Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized. By screening this focused library upon intravenous injection to BALB/c mice, ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion, and ECYPEG was found to be a superior candidate for vasculature imaging. They have potentials in intraoperative imaging. & COPY; 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.