文献类型：期刊文献

英文题名：Organocatalytic, Asymmetric, One-Pot, Three-Component Mannich Reaction of Hydroxyacetone

作者：Gu, Qing;Jiang, Ling-Xia;Yuan, Kui;Zhang, Lei;Wu, Xin-Yan[1]

机构：[1]E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2008

卷号：38

期号：23

起止页码：4198

外文期刊名：SYNTHETIC COMMUNICATIONS

收录：;EI(收录号：20242616464673);WOS:【SCI-EXPANDED(收录号:WOS:000260608700014)，CCR-EXPANDED(收录号:WOS:000260608700014)】；

基金：We thank the National Natural Science Foundation of China (20402004) and the Science Foundation of Shanghai Municipality (06ZR14028) for financial support.

语种：英文

外文关键词：Amino alcohol; asymmetric Mannich reaction; enantioselectivity; hydroxyacetone; organocatalysis

摘要：The direct three-component asymmetric Mannich reactions of hydroxyacetone with anilines and aromatic aldehydes in the presence of (2S,5S)-5-(methoxycarbonyl)pyrrolidine-2-carboxylic acid afforded syn-1,2-amino alcohols in good-to-excellent yields (5591%) and up to 98% ee.