文献类型：期刊文献

英文题名：Synthesis of 2-arylbenzofuran-3-carbaldehydes via an organocatalytic [3+2] annulation/oxidative aromatization reaction

作者：Zhang, Huiwen;Ma, Chunmei;Zheng, Ziwei;Sun, Rengwei;Yu, Xinhong[1];Zhao, Jianhong[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactors, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2018

卷号：54

期号：39

起止页码：4935

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000435872900008)，CCR-EXPANDED(收录号:WOS:000435872900008)】；

基金：We gratefully acknowledge financial support from the National Natural Science Foundation of China (21476078).

语种：英文

摘要：A novel organocatalytic [3+2] annulation/oxidative aromatization reaction of enals with 2-halophenols or beta-naphthols is reported. This process enables chemo- and regioselective access to 2-arylbenzofuran-3-carbaldehydes without the use of transition metals or strong oxidants. Preliminary mechanistic studies reveal that an unprecedented, organocatalytic, direct ce-arylation pathway is involved.