文献类型：期刊文献

英文题名：Pd-Catalyzed Direct C-H Activation for the C5-Olefination of Methyleneindolinones

作者：Xu, Xian-Kuan[1,2];Liu, Jian-Wei[1,2];Li, Deng-Yuan[1,2];Liu, Pei-Nian[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：86

期号：10

起止页码：7288

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20212210415189);WOS:【SCI-EXPANDED(收录号:WOS:000656056500025)，CCR-EXPANDED(收录号:WOS:000656056500025)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 21925201 and 91845110), the Natural Science Foundation of Shanghai (20ZR1414200), the Program of the Shanghai Committee of Sci. & Tech. (18520760700), the Program for Eastern Scholar Distinguished Professor, and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Catalysis - Palladium compounds - Activation analysis

摘要：The direct C-H activation without directing groups can realize the para-selectivity, which is a powerful and concise approach for functionalization of arenes. Utilizing the strategy, a C5-olefination of methyleneindolinones has been successfully developed by palladium-catalyzed direct C-H activation, which provides an expeditious access to 5-vinylindolin-2-ones with high regioselectivity. The protocol is distinguished by a mild reaction system avoiding ligand and high temperature. The kinetic isotope experiments indicate that the C-H bond cleavage is the rate-limiting step.