文献类型：期刊文献

英文题名：A Photoregulated DNA-Based Rotary System and Direct Observation of Its Rotational Movement

作者：Yang, Yangyang[1,2,4];Tashiro, Ryu[3];Suzuki, Yuki[2,5];Emura, Tomoko[2];Hidaka, Kumi[2];Sugiyama, Hiroshi[1,2];Endo, Masayuki[1]

机构：[1]Kyoto Univ, Inst Integrated Cell Mat Sci WPI iCeMS, Sakyo Ku, Yoshida Ushinomiyacho, Kyoto 6068501, Japan;[2]Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kitashirakawa Oiwakecho, Kyoto 6068502, Japan;[3]Suzuka Univ Med Sci, Fac Pharmaceut Sci, 3500-3 Minanitamagakicho, Suzuka, Mie 5138670, Japan;[4]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[5]Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Aoba Ku, Aramaki Aza Aoba 6-3, Sendai, Miyagi 9808578, Japan

年份：2017

卷号：23

期号：16

起止页码：3979

外文期刊名：CHEMISTRY-A EUROPEAN JOURNAL

收录：;EI(收录号：20170803379163);WOS:【SCI-EXPANDED(收录号:WOS:000397505400024)】；

基金：This work was supported by a Grant-in-Aid for Scientific Research on innovative areas "Molecular Robotics " (Grant Number 24104002) of MEXT, and JSPS KAKENHI (Grant Number 15H03837, 16K14033) to ME. Financial supports from the Novartis Foundation and the Naito Foundation to M.E. are acknowledged. Y. Yang was supported by JSPS and the Shanghai Sailing Program.

语种：英文

外文关键词：DNA; high-speed AFM; molecular wires; photochemistry; nanotechnology

摘要：Various DNA-based nanodevices have been developed on the nanometer scale using light as regulation input. However, the programmed controllability is still a major challenge for these artificial nanodevices. Herein, we demonstrate a rotary DNA nanostructure in which the rotations are controlled by light. A bar-shaped DNA rotor, fabricated as a stiff double-crossover molecule, was placed on the top of a rectangular DNA tile. The photoresponsive oligonucleotides modified with azobenzenes were employed as switching motifs to release/trap the rotor at specific angular position on DNA tile by switching photoirradiations between ultraviolet and visible light. As a result, two reconfigurable states (perpendicular and parallel) of rotor were obtained, in which the angular changes were characterized by AFM and fluorescence quenching assays. Moreover, the reversible rotary motions during the photoirradiation were directly visualized on the DNA tile surface in a nanometer-scale precision using a second-scale scanning of the high-speed AFM.