文献类型：期刊文献

英文题名：Heterobicyclic Core Retained Hydroarylations through C-H Activation: Synthesis of Epibatidine Analogues

作者：Li, Deng-Yuan;Huang, Zheng-Lu;Liu, Pei-Nian[1]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai Key Lab Funct Mat Chem, Meilong Rd 130, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2018

卷号：20

期号：7

起止页码：2028

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000429886900079)，CCR-EXPANDED(收录号:WOS:000429886900079)】；

基金：This work was supported by the National Natural Science Foundation of China (Project Nos. 21602059, 21561162003, and 21672059), the Eastern Scholar Distinguished Professor Program, the China Postdoctoral Science Foundation (2016T90341), and the Fundamental Research Funds for the Central Universities.

语种：英文

摘要：The heterobicyclic core retained hydroarylation of oxa/azabenzonorbornadienes with quinoline N-oxides has been achieved under rhodium catalysis, giving quinoline N-oxide substituted heterobicyclic structures with excellent regioselectivity and in good yields. As the first example of the direct introduction of quinoline N-oxides onto heterobicyclic structures, the strained heterobicyclic core was well retained in the reaction. The products could be successfully transformed into a series of useful compounds, including epibatidine analogues.