文献类型：期刊文献

英文题名：Targeted and NIR light-controlled delivery of nitric oxide combined with a platinum(IV) prodrug for enhanced anticancer therapy

作者：Shi, Shu-Wen[1];Li, Yan-Hui[1];Zhang, Qian-Ling[2];Yang, Shi-Ping[3,4];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[3]Shanghai Normal Univ, MOE, Key Lab Resource Chem, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2019

卷号：7

期号：11

起止页码：1867

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20191106634433);WOS:【SCI-EXPANDED(收录号:WOS:000461424000017)】；

基金：This study was financially supported by the National Nature Science Foundation of China (no. 21571062, 21271072 to JGL; 21471101, 21671137 to QLZ), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to JGL, the Shenzhen Government's Plan of Science and Technology (JCY20150324140036843) to QLZ, and the Fundamental Research Funds for the Central Universities (no. 222201717003).

语种：英文

外文关键词：Nitric oxide - Doping (additives) - Ruthenium compounds - Platinum compounds - Semiconductor quantum dots

摘要：This study reports a strategy of combining a Pt(IV) prodrug and a ruthenium nitrosyl (Ru-NO) donor into a single nanoplatform {N-GQDs@Ru-NO-Pt@FA} in which the platinum(IV) prodrug is conjugated onto a photoactivatable NO donor (Ru-NO) through a covalent bond and the nitric oxide-releasing platinum prodrug and folate groups are decorated on N-doped graphene quantum dots (N-GQDs). After cellular uptake of the nanoplatform, the platinum(IV) prodrug was reduced to an active anti-cancer Pt(II) species inside the cancerous cells, and simultaneously, near-infrared (NIR) light illumination induced the release of NO, accompanied by a prominent photothermal effect. This nanoplatform is capable of targeting intracellular co-delivery of Pt(II) and NO under 808 nm NIR light irradiation, accompanied by photothermal therapy, thereby leading to a significant synergistic therapeutic effect.