文献类型：期刊文献

英文题名：Amphiphilic random polycarbonate self-assemble into GSH/pH dual responsive micelle-like aggregates in water

作者：Hu, Jieni[1];Xu, Yue[1];Zhang, Yan[1,2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn East, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China

年份：2019

卷号：30

期号：12

起止页码：2039

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000506722300010)】；

基金：This work was supported by the National Natural Science Foundation of China (Nos. 51873062, 81673018), Shanghai Natural Science Foundation (No. 17ZR1407100), School of Pharmacy, Fudan University & The Open Project Program of Key Lab of Smart Drug Delivery (Fudan University, Nos. SDD2017-04, SDD2019-01).

语种：英文

外文关键词：Polycarbonate; Dual responsive; Micelles; Ring-opening polymerization; Random copolymers

摘要：Responsive polymers have been playing an increasingly important role in a wide variety of applications, such as biomedical materials and biosensors. Herein, we reported a dual-responsive polycarbonate (poly (MN-co-MSS)) based on the macrocyclic Sulfur/Nitrogen-substituted carbonate monomer (MSS/MN) via an enzyme-catalyzed ring-opening copolymerization and Lipase CA Novozym-435 as catalyst, with the disulfide and tertiary amine groups situated on the backbone. The structure of the random copolymers was confirmed by NMR and FTIR. In addition, size exclusion chromatography (SEC) results indicated that the copolymer had a symmetric peak and a relatively narrow polydispersity. Also, the random copolymers can self-assemble into micelle-like aggregates in water due to the hydrophilicity endowed by the amino groups, and the aggregates exhibited rich pH and GSH responsive behavior, which was verified by zeta masters instrument and dynamic light scattering (DLS). Moreover, transmission electron microscopy (TEM) demonstrated the morphology of the micellar aggregates and the variation subjected to the lower pH and GSH, and the responsive mechanism was elaborated. Therefore, these results highlighted a facile synthesis of the environment-responsive polymers and provided a novel GSH/pH responsive material platform for further application. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.