文献类型：期刊文献

中文题名：妥布霉素对磷酸钙骨水泥性能的影响

英文题名：INFLUENCE OF TOBRAMYCIN ON PROPERTIES OF CALCIUM PHOSPHATE CEMENT

作者：黄粤[1];刘昌胜[1];邵慧芳[1];刘壮峻[1]

机构：[1]华东理工大学材料工程学院,上海200237

年份：2002

卷号：21

期号：5

起止页码：417

中文期刊名：中国生物医学工程学报

外文期刊名：Chinese Journal of Biomedical Engineering

收录：CSTPCD;;EI(收录号：2002467211678);Scopus;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

基金：国家"8 63"计划资助项目 (715 0 0 9 0 10 0 )

语种：中文

中文关键词：磷酸钙骨水泥;骨修复;妥布霉素;水化

外文关键词：Calcium phosphate cement; Bone repair; Tobramycin; Hydration

摘要：本文研究了载有妥布霉素的磷酸钙骨水泥体系的应用性能 ,包括体系的凝结时间、抗压强度、水化产物及微结构分析。结果表明 ,药物的引入并未影响材料水化产物的组成。随着药物含量的提高 ,凝结时间延长 ,抗压强度下降 ,这是由于药物的存在导致了骨水泥颗粒间的反凝聚。但材料在模拟体液中静置一周后 ,强度比缓释前均有不同程度提高 ,并趋于 36MPa,同时呈经沉淀 溶解 再水化过程形成的针状水化产物生成。
Calcium phosphate cement(CPC), as a kind of novel biomaterial for repairing bone defects, has received much attention because of its high biocompatibility and self setting capability. We studied the properties of tobramycin loaded CPC system, including the setting time, compressive strength, hydrating products and microstructural development. The results showed that the introduction of the drug had no effect on the final hydrating products. With the rise of the drug content, the setting time was prolonged, and the strength dropped gradually, which was due to the anti agglomeration among the CPC particles as a result of the existence of the drug. However, after incubation in the simulated body fluid a week, the strength of the material would rise and could reach about 36MPa. The compactness of the microstructure also increased, some of which would from acicular hydrating products. This proved that CPC underwent a process of rehydration in the simulated body fluid, which made the hydrating products more compact. All these results would have some guiding significance in the clinical application of this material.