文献类型：期刊文献

英文题名：A sandcastle worm-inspired strategy to functionalize wet hydrogels

作者：Zhang, Donghui[1];Liu, Jingjing[1];Chen, Qi[2];Jiang, Weinan[2];Wang, Yibing[1,3];Xie, Jiayang[2];Ma, Kaiqian[2];Shi, Chao[2];Zhang, Haodong[2];Chen, Minzhang[2];Wan, Jianglin[2];Ma, Pengcheng[2];Zou, Jingcheng[2];Zhang, Wenjing[2];Zhou, Feng[4];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ,Res Ctr Biomed Mat, Key Lab Ultrafine Mat,Frontiers Sci Ctr Materiobi, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Biotechnol, Biomed Nanotechnol Ctr, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China

年份：2021

卷号：12

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000714451200004)】；

基金：This research was supported by the National Natural Science Foundation of China for Innovative Research Groups (51621002), the National Natural Science Foundation of China (21774031, 31800801), Program of Shanghai Academic/Technology Research Leader (20XD1421400), Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism grant 2021 Sci & Tech 03-28 (Shanghai Municipal Education Commission), Research program of State Key Laboratory of Bioreactor Engineering, and Fundamental Research Funds for the Central Universities (JKD01211520). The authors also thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization.

语种：英文

摘要：Functionalisation of hydrogels can be difficult to achieve and often requires modification of polymers before gelation. Here, the authors report on a sandcastle worm inspired adhesive tripeptide for the post gelation functionalisation of wet hydrogels, demonstrating the addition of different functionality. Hydrogels have been extensively used in many fields. Current synthesis of functional hydrogels requires incorporation of functional molecules either before or during gelation via the pre-organized reactive site along the polymer chains within hydrogels, which is tedious for polymer synthesis and not flexible for different types of hydrogels. Inspired by sandcastle worm, we develop a simple one-step strategy to functionalize wet hydrogels using molecules bearing an adhesive dibutylamine-DOPA-lysine-DOPA tripeptide. This tripeptide can be easily modified with various functional groups to initiate diverse types of polymerizations and provide functional polymers with a terminal adhesive tripeptide. Such functional molecules enable direct modification of wet hydrogels to acquire biological functions such as antimicrobial, cell adhesion and wound repair. The strategy has a tunable functionalization degree and a stable attachment of functional molecules, which provides a tool for direct and convenient modification of wet hydrogels to provide them with diverse functions and applications.