文献类型：期刊文献

英文题名：The effect of a P123 template in mesopores of mesocellular foam on the controlled-release of venlafaxine

作者：Tang, Jing[1];Bian, Zijun[1];Hu, Jun[1];Xu, Shouhong[1];Liu, Honglai[1]

机构：[1]E China Univ Sci & Technol, Dept Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2012

卷号：424

期号：1-2

起止页码：89

外文期刊名：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000301906300012)】；

基金：Financial support for this work was provided by the National Natural Science Foundation of China (Nos. 21076071 and 21176066) and the 111 Project (Grant No. B08021) of China. We also appreciated the suggestions of Prof. Richard Schwenz from the University of Northern Colorado.

语种：英文

外文关键词：Mesocellular foam; P123; Controlled-release; Venlafaxine

摘要：A series of mesocellular foams (MCFs)-based mesoporous silica nanospheres (DH-MCF-P123-n, (n = 12, 2, 0.5)) were synthesized as controlled-release deliveries for a typical antidepressant drug, venlafaxine. The foams were 3-(2,3-dihydroxypropoxyl)propyl-grafted and the P123 template partially preserved. We studied the release profiles of venlafaxine-loaded DH-MCF-P123-n in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively, as well as their corresponding venlafaxine loading capacities. Appropriate amounts of P123 template preserved in mesopores showed an efficient synergetic effect on increasing venlafaxine loading capacity and controlled-release property. Up to 90.87% (mass fraction) of venlafaxine could be loaded into DH-MCF-P123-2. For this carrier, 36% of venlafaxine was released after 1 h of incubation in SGF and 53% of venlafaxine was released after 12 h in SIF. The mechanisms of the loading and releasing processes were tentatively described based on the release behaviors. (C) 2011 Elsevier B.V. All rights reserved.