文献类型：期刊文献

英文题名：Applicatons of Genome-Scale Metabolic Models in Biotechnology and Systems Medicine

作者：Zhang, Cheng[1];Hua, Qiang[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai, Peoples R China

年份：2016

卷号：6

外文期刊名：FRONTIERS IN PHYSIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000367849600001)】；

基金：This work was funded by National Basic Research Program of China (973 Program) (2012CB721101), and China Scholarship Council.

语种：英文

外文关键词：genome-scale metabolic models; systems biology; metabolic capability analysis; in silico metabolic engineering; systems medicine

摘要：Genome-scale metabolic models (GEMs) have become a popular tool for systems biology, and they have been use dinmany fields such as industrial biotechnology and system smedicine. Since moreand more studies are being conducted using GEMs, they have recently received consider able attention. In this review, we introduce the basic concep to fGEMs and provide an overview of their applications in biotechnology, systems medicine, and some other fields. In addition, we describe the general principleof the applications and analyses built on GEMs. The purpose of this reviewis to introduce the application of GEMs in biological analysis and to promote its wider use by biologists.