文献类型：期刊文献

中文题名：An Efficient Synthesis of(+)-Subersic Acid

作者：Jing Wang[1];Peiqiang Wang[1];Jue Li[1];Peiying Wu[3];Jiangmeng Ren[1];Bubing Zeng[1,2]

机构：[1]Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China;[3]School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

年份：2015

卷号：33

期号：6

起止页码：679

中文期刊名：Chinese Journal of Chemistry

外文期刊名：中国化学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2015_2016】；PubMed;

基金：supported by the National Natural Science Foundation of China(No.21302053);Science and Technology Commission of Shanghai Mu-nicipality(No.14DZ1900102);the Fundamental Research Funds for the Central University(No.WY1113007).

语种：英文

中文关键词：(+)-subersic acid;(?)-Sclareol;cross coupling;Heck reaction

摘要：This paper describes a concise and practical route to(+)-subersic acid from naturally occurring(?)-Sclareol in 7 steps.The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed byβ-acetoxy elimination type Heck reaction.