文献类型：期刊文献

英文题名：Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice

作者：Miao, Shu-Ting[1];Lu, Qian-Shan[1];Zhou, Ying-Jun[1];Chang, Ya-Ning[1];Xu, Tao[2];Zhu, Meng-Yu[1]

机构：[1]East China Univ Sci & Technol, Coll Bioengn, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Huzhou Shengtao Biotech LLC, Huzhou, Zhejiang, Peoples R China

年份：2022

卷号：46

期号：10

外文期刊名：JOURNAL OF FOOD BIOCHEMISTRY

收录：;EI(收录号：20222612268002);WOS:【SCI-EXPANDED(收录号:WOS:000814871000001)】；

语种：英文

外文关键词：gut bacteria; octacosanol; ulcerative colitis

摘要：Octacosanol (Oct), a kind of long-chain fatty alcohol extracted from rice bran was applied to study its effects on alleviating ulcerative colitis (UC). Oct was orally administered at 10 mg/kg (Oct-L) and 30 mg/kg (Oct-H) to dextran sulfate sodium (DSS)-induced mice. Here, we reported that oral administration of 30 mg/kg Oct can significantly prevent the weight loss, colon shortening, and decrease the disease activity index (DAI) score. Oct-H supplementation modified the intestinal flora by lowering the Firmicutes/Bacteroidetes (F/B) ratio, increasing the abundance of Prevotellaceae, S24-7, Turicibacter, and meanwhile decreasing Enterococcus and Stenotrophomonas. Based on the PICRUSt2 analysis, Oct-H may exert effects by anti-inflammation and xenobiotics degradation. Furthermore, short-chain fatty acids (SCFAs) levels were raised and the integrity of the gut barrier was protected. In conclusion, Oct-H can relieve clinical symptoms, modulate the gut bacteria and protect the intestinal barrier in UC mice, suggesting the potential of Oct as a food supplementation in alleviating UC. Practical Applications Ulcerative colitis (UC) is a hard-to-cure disease, with increasing morbidity in recent years. Therefore, finding out a food supplement to alleviate UC is very meaningful. In this work, we showed that octacosanol significantly alleviated ulcerative colitis in mice. We revealed, for the first time, octacosanol's effects on protecting the integrity of the gut barrier, modulating the intestinal flora and its metabolism (SCFAs). Therefore, octacosanol was expected to prevent colitis in an all-round way. Our research might also lay the theoretical foundation for the further development of related functional foods.