文献类型：期刊文献

英文题名：Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real-Time Monitoring and Promotion of Wound Healing

作者：Zheng, Kaikai[1];Tong, Yu[2,3];Zhang, Shihao[4];He, Ruiying[1];Xiao, Lan[5];Iqbal, Zoya[4];Zhang, Yuhong[1];Gao, Jie[6];Zhang, Lei[7,8];Jiang, Libo[9];Li, Yulin[1,4]

机构：[1]Hubei Univ, Collaborat Innovat Ctr Adv Organ Chem Mat Coconst, Coll Chem & Chem Engn,Key Lab Green Preparat & Ap, Key Lab Synth & Applicat Organ Funct Mol,Minist E, Wuhan 430062, Peoples R China;[2]Hangzhou Med Coll, Dept Orthoped Surg, Zhejiang Prov Peoples Hosp, Hangzhou 310014, Peoples R China;[3]Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China;[5]Queensland Univ Technol, Ctr Biomed Technol, Brisbane, Qld 4059, Australia;[6]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[7]Hangzhou Med Coll, Dept Plast & Reconstruct Surg, Zhejiang Prov Peoples Hosp, Hangzhou 310014, Peoples R China;[8]Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Peoples R China;[9]Fudan Univ, Zhongshan Hosp, Dept Orthopaed Surg, Shanghai 200032, Peoples R China

年份：2021

卷号：31

期号：34

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20212510536097);WOS:【SCI-EXPANDED(收录号:WOS:000662306900001)】；

基金：K.Z. and Y.T. contributed equally to this work. This research was supported by the National Key R&D Program of China (2018YFE0201500), the National Natural Science Foundation of China (81772317, 51973060, 82072051, and 81771964), the National Natural Science Foundation of China for Innovative Research Groups (51621002), and a funding grant from the Shanghai International Cooperation Program (15520721200). The funding from the CHUTIAN Scholar Project of Hubei Province was also acknowledged.

语种：英文

外文关键词：antibacterial; pH-sensitive chitosan-based hydrogels; polyacrylamide; smart real-time monitoring; wound healing

摘要：Real-time monitoring of wound healing remains a major challenge in clinical tissue regeneration, calling the need for the development of biomaterial-guided on-site monitoring wound healing technology. In this study, multifunctional double colorimetry-integrated polyacrylamide-quaternary ammonium chitosan-carbon quantum dots (CQDs)-phenol red hydrogels are presented, aiming to simultaneously detect the wound pH level, reduce bacterial infection, and promote wound healing. The hybridization of CQDs and pH indicator (phenol red) with the hydrogels enables their high responsiveness, reversibility, and accurate indication of pH variability to reflect the dynamic wound status in the context of both ultraviolet and visible light. Furthermore, these visual images can be collected by smartphones and converted into on-site wound pH signals, allowing for a real-time evaluation of the wound dynamic conditions in a remote approach. Notably, the hydrogels exhibit excellent hemostatic and adhesive properties, maintain sufficient wound moisture, and promote wound healing via their high antibacterial activity (against Staphylococcus Aureus, and Escherichia Coli) and skin repair function. Overall, the resulting hydrogels have high potential as a novel smart and flexible wound dressing platform for theranostic skin regeneration.