文献类型：期刊文献

英文题名：Multivalent Glycosheets for Double Light Driven Therapy of Multidrug-Resistant Bacteria on Wounds

作者：Hu, Xi-Le[1,2];Chu, Linyang[3];Dong, Xiaojing[4];Chen, Cuo-Rong[1,2];Tang, Tingting[3];Chen, Daijie[4,5];He, Xiao-Peng[1,2];Tian, He[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong RD, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Int Res Lab Precis Chem & Mol Engn, 130 Meilong RD, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China;[4]China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, State Key Lab New Drug & Pharmaceut Proc, Shanghai 200040, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan RD, Shanghai 200240, Peoples R China

年份：2019

卷号：29

期号：14

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20190706491501);WOS:【SCI-EXPANDED(收录号:WOS:000467109100001)】；

基金：All experimental procedures were approved and performed in accordance with the guidelines of the Animal Ethics Committee of Shanghai Ninth People's Hospital (protocol registry number: A-2016-017). The authors thank the Natural Science Foundation of China (nos. 91853201, 21722801, 21776078, 81573329, and 81872775) and Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03) for generous financial support.

语种：英文

外文关键词：light-driven; multidrug-resistant bacteria; multivalent; thin-layer material; wounds

摘要：With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose- and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: 1) near-infrared-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and 2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clinically isolated P. aeruginosa.