文献类型：期刊文献

英文题名：Incorporating quantum dots into polymer microspheres via a spray-drying and thermal-denaturizing approach

作者：Chu, Maoquan[1]; Zhou, Lihui[2]; Song, Xin[1]; Pan, Min[1]; Zhang, Lihui[3]; Sun, Ye[3]; Zhu, Jian[1]; Ding, Zuquan[1]

机构：[1]Tongji Univ, Inst Life Sci & Technol, Shanghai 200092, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 2000032, Peoples R China

年份：2006

卷号：17

期号：6

起止页码：1791

外文期刊名：NANOTECHNOLOGY

收录：;EI(收录号：2006159820705);WOS:【SCI-EXPANDED(收录号:WOS:000236711900041)】；

语种：英文

外文关键词：Cadmium alloys - Dispersions - Fluorescence - Nanostructured materials - Proteins - Thermal effects

摘要：Bovine serum albumin (BSA) microspheres incorporated with CdTe quantum dots (QDs) have been prepared via a spray-drying and thermal-denaturizing approach. The results show that the morphology of the composites obtained was greatly affected by the inlet temperature and the initial concentration of BSA in the precursor. Most of the composites prepared with 0.6 mM BSA in the precursor at 40 degrees C were spherical in shape and hollow. The thermal-denaturized microspheres were water-insoluble, and separated from each other after dispersing in water. Each microsphere had bright fluorescence with pure colour. The microspheres without thermal-denaturation dissolved easily in water, and released nanospheres (> 8 nm) that consisted of many CdTe nanoparticles (< 3 nm). This approach opens the possibility of rapidly preparing QDs microspheres with controlled fluorescence intensity or with separated multiemission peaks for biomedical applications.