文献类型：期刊文献

英文题名：Characteristics of bicalutamide solid dispersions and improvement of the dissolution

作者：Ren, Fuzheng; Jing, Qiufang; Tang, Yanhui; Shen, Yongjia; Chen, Jialei; Gao, Feng; Cui, Jingbin

机构：[1]E China Univ Sci & Technol, Sch Chem & Pharmaceut, Dept Pharmaceut Engn, Shanghai 200237, Peoples R China

年份：2006

卷号：32

期号：8

起止页码：967

外文期刊名：DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000240339800007)】；

语种：英文

外文关键词：bicalutamide; solid dispersion; PVPK30; dissolution rate; amorphous state

摘要：The purpose of our study was to formulate and evaluate bicalutamide (BL) solid dispersions (SD). The physicochemical properties were evaluated by differential scanning calorimetry (DSC), Fourier-Transform infrared (FT-IR) spectroscopy, Powder X-ray diffractometry (PXRD), dissolution studies, and stability studies. The dissolution studies demonstrated that the dissolution of BL from BL-SD increased with an increase in carrier content (PVP K30). X-ray assays and DSC results both confirmed the amorphous state of BL in BL-SD. Stability studies conducted after 6 months showed that BL exhibited excellent stability in the solid dispersion of PVP K30 (1:5).