文献类型：期刊文献

英文题名：Synthesis of difluoromethylene-containing 1,2,4-oxadiazole compounds via the reaction of 5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole with unsaturated compounds initiated by sodium dithionite

作者：Yang, Xueyan[1]; Wang, Zhonghua[1]; Fang, Xiang[1]; Yang, Xianjin[1]; Wu, Fanhong[1,2]; Shen, Yongjia[1]

机构：[1]E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200232, Peoples R China

年份：2007

期号：12

起止页码：1768

外文期刊名：SYNTHESIS-STUTTGART

收录：;EI(收录号：20072810695661);WOS:【SCI-EXPANDED(收录号:WOS:000247726100004)】；

语种：英文

外文关键词：difluoromethylene; 1,2,4-oxadiazole; gamma-butyrolactone; addition; cyclization

摘要：5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole, synthesized by the iodination of the corresponding zinc reagent of 5(bromodifluoromethyl)-3-phenyl-1,2,4-oxadiazole, reacted with various unsaturated compounds, such as alkenes, alkynes, pent-4-en-1-ols, and pent-4-enoic acids, in the presence of sodium dithionite and sodium hydrogen carbonate in aqueous acetonitrile solution at ambient temperature to afford various difluoromethylenated 1,2,4-oxadiazole-containing compounds, including gamma-butyrolactones and tetrahydrofurans, in moderate yields.