文献类型：期刊文献

英文题名：Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl -Fluorinated gem-Diols to N-Benzyl Isatins

作者：Saidalimu, Ibrayim[1,2];Fang, Xiang[1,2];He, Xiao-Peng[1,2];Liang, Jing[1,2];Yang, Xueyan[1,2];Wu, Fanhong[3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Chem, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai, Peoples R China

年份：2013

卷号：52

期号：21

起止页码：5566

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20132016342904);WOS:【SCI-EXPANDED(收录号:WOS:000318929200024)，CCR-EXPANDED(收录号:WOS:000318929200024)】；

基金：This work is generously supported by the National Natural Science Foundation of China (Nos. 21172148, 21202044, 21202045) and Science and Technology Commission of Shanghai Municipality (No. 10540501300).

语种：英文

外文关键词：aldol reaction; carboncarbon bond cleavage; organocatalysis; reaction mechanisms; trifluoroacetate release

摘要：An organocatalytic asymmetric direct aldol addition reaction that involves cleavage of a carbon-carbon bond through the release of trifluoroacetate was developed. The protocol is wide in scope, generating the desired oxindoles of biological interest in nearly quantitative yields (up to 99 %) with excellent enantioselectivities (up to 98 % ee) and diastereoselectivities (up to 99:1 d.r.). Copyright ? 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.