文献类型：期刊文献

英文题名：Zinc-Catalyzed Alkylation of Aromatic Amines in Continuous Flow

作者：Zhang, Le[1];Bo, Xiaofan[1];Yao, Hanlin[1];Mao, Mengmei[1];Wan, Li[1];Xin, Zhong[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Sch Chem Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：24

期号：10

起止页码：2078

外文期刊名：ORGANIC PROCESS RESEARCH & DEVELOPMENT

收录：;EI(收录号：20204809528754);WOS:【SCI-EXPANDED(收录号:WOS:000582583300028)，CCR-EXPANDED(收录号:WOS:000582583300028)】；

基金：This research was financially supported by the Fundamental Research Funds for the Central Universities (50321012017025).

语种：英文

外文关键词：4,4 '-dicumyldiphenylamine; alkylation; styrene; continuous flow

摘要：A practical approach to the synthesis of antioxidant 4,4'-dicumyldiphenylamine (DCDPA) and its derivatives by Friedel-Crafts alkylation of aromatic amines was developed under continuous flow conditions. Because of the enhanced mass and heat transfer features of the microreactor, the reaction time was significantly reduced in contrast to a batch mode. The reaction was carried out using a 1:6 v/v ethanol/Cl(CH2)(2)Cl cosolvent system with ZnCl2 as the catalyst to achieve satisfactory yields. This is an effective method for the synthesis of DCDPA and its derivatives with excellent para selectivity that has the merits of shorter reaction time, easy operation, and straightforward scale-up.