文献类型：期刊文献

英文题名：Controllable fabrication of porous PLGA/PCL bilayer membrane for GTR using supercritical carbon dioxide foaming

作者：Song, Chaobo[1]; Li, Shuang[2]; Zhang, Jiapeng[1]; Xi, Zhenhao[1]; Lu, Eryi[2]; Zhao, Ling[1]; Cen, Lian[1]

机构：[1] Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Department of Stomatology of Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China

年份：2019

卷号：472

起止页码：82

外文期刊名：Applied Surface Science

收录：EI(收录号：20181805131036)

语种：英文

外文关键词：Tensile strength - Tissue regeneration - Fabrication - Tensile testing - Pore size - Carbon dioxide - Supercritical fluid extraction - Cell culture

摘要：In present study, an efficient solvent-free foaming method aided by supercritical carbon dioxide (sc-CO2) is developed to prepare porous PLGA/PCL bilayer membranes for potential guided tissue regeneration (GTR) applications. First rheological properties and foaming behaviors of PLGA and PCL were studied in detail. Compared with PLGA, PCL had lower viscosity with loss tangent tan δ over 1 thus got bigger and highly interconnected pores after foaming. Based on this, membranes with distinct porous PCL and PLGA bilayer were prepared via a one-step foaming. SEM showed the pore size of the PCL layer was 80–100 μm, and that of the PLGA layer was less than 10 μm. Through tensile tests these membranes exhibited a tensile strength of 4.02 MPa and a elongation at break of 57.7 %, meeting the mechanical requirements of GTR. Further cell tests demonstrated that the PCL layer suited for the proliferation of osteoblasts and the PLGA layer inhibited the ingrowth of fibroblasts. The porous PLGA/PCL bilayer membranes fabricated using this one-step foaming meet the requirements of GTR and possess great commercial potential. ? 2018 Elsevier B.V.