文献类型：期刊文献

英文题名：Polyketide pesticides from actinomycetes

作者：Li, Shanshan[1];Yang, Bowen[2];Tan, Gao-Yi[2];Ouyang, Li-Ming[2];Qiu, Shiwen[3,4];Wang, Weishan[2,3,5];Xiang, Wensheng[1,4];Zhang, Lixin[2]

机构：[1]Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100101, Peoples R China;[4]Northeast Agr Univ, Sch Life Sci, Harbin 150030, Peoples R China;[5]Univ Chinese Acad Sci, Beijing 100049, Peoples R China

年份：2021

卷号：69

起止页码：299

外文期刊名：CURRENT OPINION IN BIOTECHNOLOGY

收录：;EI(收录号：20212310470793);WOS:【SCI-EXPANDED(收录号:WOS:000665520200035)】；

基金：This work was supported by the National Key R&D program of China (2020YFA0907800), the National Natural Science Foundation of China (31922002, 31772242, 31972348), and the Young Scientists Innovation Promotion Association of CAS (202027) to W.W. We appreciated Prof Lisheng Zhang and Dr Yuyan Li from Institute of Plant Protection, Chinese Academy of Agricultural Sciences for providing pictures about crop protection.

语种：英文

外文关键词：Crop protection - Metabolites - Bacteria

摘要：Natural product derived pesticides have increased in popularity worldwide because of their high efficacy, eco-friendly nature and favorable safety profile. The development of polyketide pesticides from actinomycetes reflects this increase in popularity in the past decades. These pesticides, which include avermectins, spinosyns, polynactins, tetramycin and their analogues, have been successfully applied in crop protection. Moreover, the advance of biotechnology has led to continuous improvement in the discovery and production processes. In this review, we summarize these polyketide pesticides, their activities and provide insight into their development. We also discuss engineering strategies and the current status of industrial production for these pesticides. Given that actinomycetes are known to produce a wide range of bioactive secondary metabolites, the description of pesticide development and high yield strain improvement presented herein will facilitate further development of these valuable polyketide pesticides from actinomycetes.