文献类型：期刊文献

英文题名：A pH-resistant Zn(II) sensor derived from 4-aminonaphthalimide: design, synthesis and intracellular applications

作者：Wang, Jiaobing[1]; Xiao, Yi[1]; Zhang, Zhichao[1]; Qian, Xuhong[1,2]; Yang, Yuanyuan[1]; Xu, Qin[1]

机构：[1]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2005

卷号：15

期号：27-28

起止页码：2836

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY

收录：;EI(收录号：2005329283143);WOS:【SCI-EXPANDED(收录号:WOS:000230431900028)】；

语种：英文

外文关键词：Electron transitions - Fluorescence - Molecular structure - pH effects - Quenching - Synthesis (chemical) - Zinc

摘要：The development and intracellular applications of a water-soluble Zn(II) sensor (WZS) are described. 4-Aminonaphthalimide is used as the fluorophore of WZS for its high photostability, long excitation and emission wavelength, large Stokes' shift and inert response to pH. N,N- Bis(2pyridylmethyl) ethylenediamine (BPEN), used as a receptor for Zn( II), is attached to the fluorophore through a rigid benzene framework on the imide moiety. Spectroscopic studies indicate that this fluorophore-receptor linking strategy could be used for the development of effective photoinduced electron transfer (PET) sensors. WZS is pH-insensitive and shows high selectivity for Zn(II) against other biologically relevant metal ions. Cellular applications revealed that WZS could be used for the imaging of intracellular Zn(II).