文献类型：期刊文献

英文题名：Peptide-mimicking poly(2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria

作者：Cong, Zihao[1];Yan, Zi[2];Xiao, Ximian[2];Liu, Longqiang[2];Luo, Zhengjie[2];Zou, Jingcheng[2];Chen, Minzhang[2];Wu, Yueming[2];Zhou, Min[1,2];Liu, Runhui[1,2,3]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine M, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China

年份：2025

卷号：214

起止页码：233

外文期刊名：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

收录：;EI(收录号：20243516932184);WOS:【SCI-EXPANDED(收录号:WOS:001301537100001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (no. 2022YFC2303100), National Natural Science Foundation of China (nos. T2325010, 22305082, 52203162, and 22075078), Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), the Fundamental Re-search Funds for the Central Universities (nos. JKVD1241029 and JKD01241701), Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences), the Open Project of Engineering Research Center of Dairy Quality and Safety Control Technology (Ministry of Education, no. R202201). The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for the help in the characterization. The authors also thank the support of the Analysis and Testing Center of School of Chemical Engineering, East China University of Science and Technology.

语种：英文

外文关键词：Poly(2-oxazoline)s; Host defense peptide; Antibiofilm; MRSA; Drug-resistance

摘要：The rising prevalence of drug-resistant Gram-positive pathogens, particularly methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE), poses a substantial clinical challenge. Biofilm-associated infections exacerbate this problem due to their inherent antibiotic resistance and complex structure. Current antibiotic treatments struggle to penetrate biofilms and eradicate persister cells, leading to prolonged antibiotic use and increased resistance. Host defense peptides (HDPs) have shown promise, but their clinical application is limited by factors such as enzymatic degradation and difficulty in large-scale preparation. Synthetic HDP mimics, such as poly(2-oxazoline), have emerged as effective alternatives. Herein, we found that the poly(2-oxazoline), Gly-POX20 , demonstrated rapid and potent activity against clinically isolated multidrug-resistant Gram-positive strains. Gly-POX20 showed greater stability under physiological conditions compared to natural peptides, including resistance to protease degradation. Importantly, Gly-POX20 inhibited biofilm formation and eradicated mature biofilm and demonstrated superior in vivo therapeutic efficacy to vancomycin in a MRSA biofilm-associated mouse keratitis model, suggesting its potential as a novel antimicrobial agent against drug-resistant Gram-positive bacteria, especially biofilm-associated infections. (c) 2024 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.